{"id":"W4409737207","doi":"10.1101/2025.04.22.650021","title":"Single cell multi-omics reveals rare biosynthetic cell types in the medicinal tree <i>Camptotheca acuminata</i>","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus","funders":"Catalyst @ Health 2.0; Georgia Research Alliance","keywords":"Camptothecin; Biology; Catharanthus roseus; Biosynthesis; MYB; Biochemistry; Gene; Transcription factor; Transcriptome; Metabolomics; Gene expression; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003130939,0.0003621142,0.0008339937,0.0007470791,0.0007928099,0.001257363,0.0004095655,0.0007482265,0.002779793],"category_scores_gemma":[0.0003950434,0.0002659743,0.0006173677,0.0007927521,0.0004006388,0.0007105353,0.0008028605,0.001126875,0.001471381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004668937,"about_ca_system_score_gemma":0.0003888562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001348335,"about_ca_topic_score_gemma":0.003862206,"domain_scores_codex":[0.9996424,0.00001418465,0.00001516089,0.0001645852,0.00009655601,0.00006723144],"domain_scores_gemma":[0.9997633,0.00005863453,0.00004746214,0.00003423745,0.00005870481,0.00003764575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001293174,0.00002026965,0.005294629,0.0003141407,0.0000456263,0.0001572726,0.0001402686,0.0003009961,0.9829761,0.0008216487,0.001373043,0.008426643],"study_design_scores_gemma":[0.00007216188,0.000386726,0.393189,0.0002503044,0.0003954803,0.002508995,0.001151391,0.01772152,0.4242895,0.007505595,0.1523007,0.0002285205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8309068,0.01013344,0.06949841,0.001289866,0.0004772968,0.0001978517,0.0738477,0.003116408,0.01053224],"genre_scores_gemma":[0.8590922,0.003575098,0.04646605,0.001797452,0.0001641912,0.0003341931,0.07931604,0.0012507,0.00800395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002779793,"threshold_uncertainty_score":0.009299278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01378346430693504,"score_gpt":0.2278640782279971,"score_spread":0.2140806139210621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}