{"id":"W4409737216","doi":"10.1016/j.stemcr.2025.102481","title":"Hypoxia and loss of GCM1 expression prevent differentiation and contact inhibition in human trophoblast stem cells","year":2025,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McGill University Health Centre; McGill University","funders":"Institute of Human Development, Child and Youth Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; National Institutes of Health; Faculty of Medicine, McGill University","keywords":"Biology; Trophoblast; Hypoxia (environmental); Cell biology; Stem cell; Andrology; Placenta; Genetics; Oxygen; Pregnancy; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644554,0.0001255903,0.000332809,0.0001118464,0.00006039627,0.000009116367,0.00001155381,0.00008356142,0.000007154465],"category_scores_gemma":[0.000003288741,0.0001054331,0.00003816494,0.00008014942,0.00004065074,0.00006223033,0.00007112186,0.000101055,1.821642e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003489511,"about_ca_system_score_gemma":0.00002579616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002338093,"about_ca_topic_score_gemma":0.000020122,"domain_scores_codex":[0.9989395,0.00005963354,0.0004684303,0.0002710404,0.000139572,0.0001218376],"domain_scores_gemma":[0.9994381,0.00004616165,0.0002415041,0.0001965417,0.00003687014,0.00004080194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001050366,0.0002052973,0.1512108,0.001527338,0.00002765897,0.0002725805,0.0009610626,0.000002057842,0.843862,0.00004546797,0.0002036749,0.001577052],"study_design_scores_gemma":[0.0009619034,0.0001552326,0.2058132,0.002582877,0.00006760431,0.00003790824,0.0002994597,0.00001135346,0.7895839,0.0003055586,0.00009595997,0.00008503766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932784,0.003655389,0.00008817526,0.00003614037,0.0001136665,0.0005191221,0.000003104521,0.00001732604,0.002288699],"genre_scores_gemma":[0.998312,0.0004129205,0.00002196257,0.00001538753,0.00001285037,0.00002641043,0.000007894936,0.000007393362,0.00118319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05460236,"threshold_uncertainty_score":0.4299438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004939057596462,"score_gpt":0.2384752584511296,"score_spread":0.228425867875165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}