{"id":"W4409737216","doi":"10.1016/j.stemcr.2025.102481","title":"Hypoxia and loss of GCM1 expression prevent differentiation and contact inhibition in human trophoblast stem cells","year":2025,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McGill University Health Centre; McGill University","funders":"Institute of Human Development, Child and Youth Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; National Institutes of Health; Faculty of Medicine, McGill University","keywords":"Biology; Trophoblast; Hypoxia (environmental); Cell biology; Stem cell; Andrology; Placenta; Genetics; Oxygen; Pregnancy; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001164297,0.0001491506,0.0001638476,0.0001634483,0.0001642034,0.0002072504,0.0001273862,0.0001961838,0.00168211],"category_scores_gemma":[0.0001330521,0.00009257063,0.0001821756,0.0001576893,0.0001826139,0.0001310825,0.0001858198,0.0003202552,0.0003479465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002810222,"about_ca_system_score_gemma":0.0002442398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001792936,"about_ca_topic_score_gemma":0.003219911,"domain_scores_codex":[0.9998924,0.0000162943,0.000009138546,0.00002740789,0.00003297341,0.00002172868],"domain_scores_gemma":[0.9999404,0.00001408813,0.00001496929,0.0000100259,0.00000534724,0.00001505555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001546893,0.00002158352,0.001015233,0.00004692695,0.000007561385,0.000119169,0.00004716425,0.00004173837,0.9954951,0.0002124812,0.00008078157,0.00275765],"study_design_scores_gemma":[0.0000112546,0.0002267491,0.01695183,0.000004797624,0.00001197903,0.000522783,0.00004627859,0.000287804,0.9738177,0.00006324043,0.008053169,0.00000243431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988236,0.004521038,0.003288016,0.0001952386,0.00003262677,0.00004634645,0.0007650742,0.00006775038,0.002847915],"genre_scores_gemma":[0.9907842,0.001322016,0.002576003,0.0000824646,0.000007243274,0.00007378852,0.001114609,0.00001520525,0.004024485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001792936,"threshold_uncertainty_score":0.005627215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004939057596462,"score_gpt":0.2384752584511296,"score_spread":0.228425867875165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}