{"id":"W4409745378","doi":"10.1186/s13195-025-01742-6","title":"Differential effects of aging, Alzheimer's pathology, and APOE4 on longitudinal functional connectivity and episodic memory in older adults","year":2025,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut Universitaire de Gériatrie de Montréal; McGill University; Douglas Mental Health University Institute","funders":"Otto von Guericke University Magdeburg; Deutsche Forschungsgemeinschaft","keywords":"Precuneus; Parahippocampal gyrus; Episodic memory; Psychology; Neuroscience; Temporal lobe; Alzheimer's disease; Hippocampus; Neurology; Posterior cingulate; Cognition; Medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006219249,0.0002060923,0.0001758084,0.0004126506,0.0002040153,0.0002686682,0.0001705461,0.000281627,0.0007321621],"category_scores_gemma":[0.001996751,0.0001053319,0.0002054049,0.0002817006,0.0001842664,0.0003149558,0.0002384478,0.0001743111,0.00009435657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001531689,"about_ca_system_score_gemma":0.0001247261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003968791,"about_ca_topic_score_gemma":0.008140274,"domain_scores_codex":[0.9998912,0.00002641283,0.00001318797,0.00003447532,0.00001390378,0.00002079896],"domain_scores_gemma":[0.999379,0.000157061,0.0002346829,0.00005409342,0.00008555652,0.00008948417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005338504,0.00004330548,0.9953269,0.000009694419,0.00008565535,0.00008073226,0.0001662003,0.00008393529,0.001060839,0.00002114848,0.00004479807,0.002542834],"study_design_scores_gemma":[0.00000264338,0.00008372303,0.9995903,0.000001292903,0.0000168836,0.00006857664,0.00003461344,0.00008961413,0.0000622964,0.00002315123,0.00002609646,8.436093e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996798,0.0000953048,0.00004051377,0.000007889476,6.629488e-7,0.000002066201,0.00006943331,0.000001230416,0.0001029729],"genre_scores_gemma":[0.9997501,0.00002828988,0.00005227493,0.000005273753,0.00000176637,0.0000027257,0.0001040931,5.979516e-7,0.00005486831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003968791,"threshold_uncertainty_score":0.007891417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0768005484332302,"score_gpt":0.3504735666026848,"score_spread":0.2736730181694546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}