{"id":"W4409765779","doi":"10.1002/cpdd.1540","title":"Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants","year":2025,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Hepatitis C virus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"","keywords":"NS5A; Medicine; Pharmacology; Drug; Adverse effect; Hepatitis C virus; NS5B; Combination therapy; Chronic hepatitis; Hepacivirus; Virus; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003554554,0.001451033,0.002085975,0.0002945103,0.0004994958,0.0004847363,0.0005584398,0.001549963,0.001773258],"category_scores_gemma":[0.002562559,0.0005665408,0.001356028,0.000297301,0.0005927794,0.0006920989,0.0003498678,0.00155213,0.0004873438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004074824,"about_ca_system_score_gemma":0.0006366859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005938338,"about_ca_topic_score_gemma":0.0008945969,"domain_scores_codex":[0.9982727,0.0009757163,0.0000729282,0.0002776501,0.000253185,0.0001477498],"domain_scores_gemma":[0.9984462,0.0003795788,0.00031114,0.0001087812,0.0002163699,0.0005379854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6466389,0.08613229,0.04092906,0.0008172187,0.002876229,0.0008038969,0.0006377648,0.001400761,0.1407885,0.00007714154,0.0008147674,0.07808352],"study_design_scores_gemma":[0.03507235,0.8885801,0.06100277,0.00001489192,0.001199118,0.000511214,0.000106667,0.001232282,0.01070414,0.00005389304,0.001474843,0.00004772956],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976348,0.0007827794,0.0003661455,0.00005638964,0.0000305118,0.0005756901,0.0002415597,0.00002333778,0.0002887514],"genre_scores_gemma":[0.996106,0.0005340459,0.001097203,0.0001943025,0.00007341938,0.0006140714,0.0005342143,0.00001568897,0.0008310874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003554554,"threshold_uncertainty_score":0.01879847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.217051315865395,"score_gpt":0.6195449109795277,"score_spread":0.4024935951141327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}