{"id":"W4409766318","doi":"10.3390/biomedicines13051034","title":"Synergistic Anticancer Activity of HSP70 Inhibitor and Doxorubicin in Gain-of-Function Mutated p53 Breast Cancer Cells","year":2025,"lang":"en","type":"article","venue":"Biomedicines","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"E-Da Hospital; I-Shou University","keywords":"Doxorubicin; Apoptosis; Thioflavin; Flow cytometry; Cancer research; Cancer cell; Chemistry; Mutant; Molecular biology; Biology; Cancer; Biochemistry; Chemotherapy; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009541746,0.0002831252,0.0004465124,0.0002609897,0.00009929654,0.0001628909,0.0001368666,0.0001878237,0.0009396882],"category_scores_gemma":[0.00006518444,0.0000977278,0.0002465303,0.0001793627,0.00009962128,0.0001086316,0.0001338757,0.0002901985,0.0002138103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001980253,"about_ca_system_score_gemma":0.0001527469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004018787,"about_ca_topic_score_gemma":0.000981021,"domain_scores_codex":[0.9999162,0.00001498985,0.000009736815,0.00001595077,0.00002333133,0.0000196723],"domain_scores_gemma":[0.9999546,0.00001061418,0.000009053063,0.000006173246,0.000008101936,0.00001150071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003629518,0.0001506388,0.0002835319,0.0001258646,0.00001846971,0.0001066058,0.0000178075,0.0002023598,0.9945592,0.00005037873,0.0001353605,0.003986844],"study_design_scores_gemma":[0.0000566799,0.001775449,0.00388544,0.00001100911,0.0000526838,0.0003559419,0.00002115228,0.0009538523,0.9905735,0.00001798553,0.002291231,0.000005163144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928571,0.004289388,0.00091434,0.0001023292,0.00004251564,0.0000483473,0.0002079896,0.00006111432,0.00147683],"genre_scores_gemma":[0.9958138,0.001869109,0.001026094,0.00003428101,0.00001060279,0.0000417895,0.0002726918,0.000006579745,0.000925054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009396882,"threshold_uncertainty_score":0.003143609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007710280645765444,"score_gpt":0.2688893374478391,"score_spread":0.2611790568020737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}