{"id":"W4409766318","doi":"10.3390/biomedicines13051034","title":"Synergistic Anticancer Activity of HSP70 Inhibitor and Doxorubicin in Gain-of-Function Mutated p53 Breast Cancer Cells","year":2025,"lang":"en","type":"article","venue":"Biomedicines","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"E-Da Hospital; I-Shou University","keywords":"Doxorubicin; Apoptosis; Thioflavin; Flow cytometry; Cancer research; Cancer cell; Chemistry; Mutant; Molecular biology; Biology; Cancer; Biochemistry; Chemotherapy; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891291,0.0001880807,0.0005628168,0.0005800264,0.00002347822,0.000003474838,0.00005501054,0.0001544771,0.000069532],"category_scores_gemma":[0.00007849005,0.0001566349,0.0000575548,0.001122195,0.0003856398,0.00004406489,0.00004463097,0.0001735292,0.000001352055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150424,"about_ca_system_score_gemma":0.0003370868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002594414,"about_ca_topic_score_gemma":0.0002095007,"domain_scores_codex":[0.9987342,0.00004694372,0.0004081671,0.0003202848,0.0002653467,0.000225096],"domain_scores_gemma":[0.9991983,0.00009516747,0.0001702252,0.0002611763,0.000188376,0.00008679037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009914873,0.0001943075,0.007569874,0.0008034033,0.0001256001,0.00002570043,0.0001326733,0.00002481048,0.9715941,0.0000505771,0.001032369,0.01745512],"study_design_scores_gemma":[0.004343048,0.0003498362,0.1695113,0.003006001,0.0004451463,0.00001511301,0.000147503,0.0009722638,0.8203764,0.00005808062,0.0006200431,0.0001552398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933276,0.002581474,0.0008077984,0.001303558,0.000977059,0.0004671565,0.00007611556,0.00003407822,0.0004251192],"genre_scores_gemma":[0.9988176,0.0005653489,0.0000549219,0.0001674586,0.0001388887,0.00002745129,0.00001270647,0.00001924654,0.0001964077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1619415,"threshold_uncertainty_score":0.6387388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007710280645765444,"score_gpt":0.2688893374478391,"score_spread":0.2611790568020737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}