{"id":"W4409771313","doi":"10.1038/s41598-025-94304-7","title":"Competitive enzyme linked aptamer based assay for salivary melatonin detection","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Royal University Hospital Foundation; International Association for Dental Research; National Institute of Dental and Craniofacial Research; Alpha Omega Foundation","keywords":"Aptamer; Melatonin; Enzyme; Saliva; Chemistry; Computational biology; Biochemistry; Molecular biology; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001954644,0.0001510568,0.0001822695,0.0004135205,0.0006553452,0.000354784,0.000243067,0.0001021017,0.0002027174],"category_scores_gemma":[0.001898407,0.0001415929,0.000155276,0.001039386,0.0004376227,0.0001188136,0.00009909207,0.0001851842,0.00003797762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001161869,"about_ca_system_score_gemma":0.0003899008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000177788,"about_ca_topic_score_gemma":0.00003454792,"domain_scores_codex":[0.9972708,0.0001941067,0.0004001872,0.001044801,0.00063876,0.0004513847],"domain_scores_gemma":[0.9982888,0.0004946879,0.0001439444,0.0006958577,0.0002483636,0.0001283282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003650781,0.00008060528,0.0002742335,0.00002622943,0.000004936495,0.00003656194,0.00004886147,0.00008449216,0.9930601,0.0008997393,0.003751683,0.001696112],"study_design_scores_gemma":[0.000187786,0.00003414308,0.0002696713,0.00002617001,0.000009241504,0.00001136192,0.00002093931,0.007142656,0.8333936,0.002652747,0.1561318,0.000119876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7546377,0.0002673498,0.08909394,0.0009037319,0.04551204,0.004801101,0.00008632044,0.0004928611,0.104205],"genre_scores_gemma":[0.9881707,0.000002518684,0.0005032552,0.0001950097,0.00005043506,0.0001678683,0.00002057091,0.00001654447,0.01087304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2335331,"threshold_uncertainty_score":0.5773992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03471674126904221,"score_gpt":0.321164900535211,"score_spread":0.2864481592661688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}