{"id":"W4409771313","doi":"10.1038/s41598-025-94304-7","title":"Competitive enzyme linked aptamer based assay for salivary melatonin detection","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Royal University Hospital Foundation; International Association for Dental Research; National Institute of Dental and Craniofacial Research; Alpha Omega Foundation","keywords":"Aptamer; Melatonin; Enzyme; Saliva; Chemistry; Computational biology; Biochemistry; Molecular biology; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008593537,0.001429191,0.0008252871,0.0006567332,0.0002476537,0.0004201841,0.0009787146,0.001904151,0.001425829],"category_scores_gemma":[0.001403473,0.0005952751,0.0005821433,0.0005316414,0.0003234084,0.0003685886,0.000450709,0.001555422,0.00107426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004551287,"about_ca_system_score_gemma":0.0003217103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003332114,"about_ca_topic_score_gemma":0.0008897565,"domain_scores_codex":[0.9981554,0.0004300027,0.0001024601,0.0005960948,0.0005969785,0.0001190892],"domain_scores_gemma":[0.9993564,0.0002540114,0.0001332469,0.00003648421,0.0001708184,0.0000489788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006077711,0.00005462868,0.0001855809,0.0002080273,0.00002084095,0.00005412215,0.00004001685,0.0001516854,0.993471,0.0001065336,0.0001929885,0.005453811],"study_design_scores_gemma":[0.00002572382,0.0008001,0.001040076,0.00002853691,0.00005159517,0.0005442133,0.000041356,0.006491404,0.9857622,0.0001252653,0.005051544,0.00003799158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3417222,0.02611338,0.617032,0.0008694907,0.001204989,0.001656137,0.001155477,0.00320176,0.007044508],"genre_scores_gemma":[0.6300047,0.006774625,0.3466688,0.001073174,0.0002482797,0.002189429,0.001035667,0.00009557106,0.01190968],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001904151,"threshold_uncertainty_score":0.004769862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03471674126904221,"score_gpt":0.321164900535211,"score_spread":0.2864481592661688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}