{"id":"W4409775561","doi":"10.1186/s13053-025-00314-x","title":"Chemotherapy receipt in affected BRCA1/2 and PALB2 carriers with operable breast cancer: the impact of early detection and pre-diagnostic awareness on clinical outcomes and treatment","year":2025,"lang":"en","type":"article","venue":"Hereditary Cancer in Clinical Practice","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé","keywords":"Medicine; PALB2; Breast cancer; Oncology; Internal medicine; Chemotherapy; Stage (stratigraphy); Cancer; Disease; Germline mutation; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008097831,0.0002093882,0.0003902509,0.00005521896,0.000071458,0.00002897372,0.00009934219,0.0002376604,0.00001292779],"category_scores_gemma":[0.001070442,0.000137104,0.00006792088,0.0002239971,0.0003375103,0.00002873391,0.00005050795,0.0003248452,1.400248e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854003,"about_ca_system_score_gemma":0.0008176076,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01437474,"about_ca_topic_score_gemma":0.01595274,"domain_scores_codex":[0.9980808,0.0005089956,0.0005512243,0.0005511682,0.0001119409,0.0001958054],"domain_scores_gemma":[0.9969243,0.002349142,0.0002075614,0.000325757,0.000114627,0.00007858258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003284694,0.0002660952,0.8637022,0.00002067454,0.0004589195,0.000007977598,0.0001193804,0.001085305,0.0001778071,0.000001866228,0.0002023473,0.1306727],"study_design_scores_gemma":[0.003926935,0.0019542,0.9921541,0.0001241995,0.0001168366,0.00001851124,0.000234996,0.0002359592,0.0003570614,0.00002003117,0.0007087297,0.0001484999],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927735,0.00370462,0.00002512596,0.002286753,0.0003364042,0.0006283007,0.000127127,0.000006518102,0.0001116208],"genre_scores_gemma":[0.9761247,0.02272931,0.0001264551,0.0005330674,0.0001747369,0.0002271386,0.000005930904,0.00001964783,0.00005901345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1305242,"threshold_uncertainty_score":0.9921886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552535964853123,"score_gpt":0.418631289595929,"score_spread":0.3931059299473978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}