{"id":"W4409782401","doi":"10.1016/j.healun.2025.02.144","title":"Prospective Multicenter Validation of Bile Acids in Large Airway Bronchial Wash (LABW) as Biomarkers of Chronic Lung Allograft Dysfunction (CLAD) Risk","year":2025,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"Medicine; Airway; Multicenter study; Internal medicine; Prospective cohort study; Lung; Gastroenterology; Intensive care medicine; Surgery; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003372747,0.0007475241,0.0007109217,0.0005273568,0.0007466922,0.001511711,0.0005659935,0.0009618831,0.0008578512],"category_scores_gemma":[0.004151648,0.000479424,0.0006665111,0.0005769539,0.0006192098,0.0008290156,0.001105321,0.0009487397,0.0005894006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004808286,"about_ca_system_score_gemma":0.0007738058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188102,"about_ca_topic_score_gemma":0.001475061,"domain_scores_codex":[0.9977666,0.0008791661,0.0001601752,0.0006039623,0.0003231614,0.0002668402],"domain_scores_gemma":[0.9968934,0.0004808959,0.0008204245,0.0006139789,0.0007213906,0.0004698986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004567131,0.000388511,0.9870468,0.00003059904,0.000300347,0.00004873368,0.0001471256,0.0001027495,0.00432977,0.00006244163,0.0002086358,0.002767081],"study_design_scores_gemma":[0.0002491011,0.002222012,0.9938864,0.00001892694,0.000218015,0.0001978706,0.0002317719,0.0006406932,0.001698817,0.00005005492,0.0005732034,0.00001312981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985274,0.0002177258,0.0003516054,0.00003328635,0.00002752418,0.00007838778,0.0004776087,0.00001201133,0.0002745022],"genre_scores_gemma":[0.9984826,0.00003906409,0.0004055877,0.00006043582,0.00002173077,0.00006932596,0.000724455,0.000008822654,0.0001879385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003372747,"threshold_uncertainty_score":0.01783699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004709020798654042,"score_gpt":0.267070623756787,"score_spread":0.262361602958133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}