{"id":"W4409787462","doi":"10.1038/s41573-025-01183-8","title":"GLP-1-based therapies for diabetes, obesity and beyond","year":2025,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Medicine; Diabetes mellitus; Obesity; Intensive care medicine; Pharmacology; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006716409,0.0008441586,0.004179825,0.0003324997,0.0001141975,0.000140979,0.0002472771,0.0005554717,0.00002253017],"category_scores_gemma":[0.0002438775,0.0005260311,0.001580577,0.0004243751,0.00008373434,0.0001824285,0.0001323701,0.0006900942,0.00001927318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001905538,"about_ca_system_score_gemma":0.0003342277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001086871,"about_ca_topic_score_gemma":0.000005020296,"domain_scores_codex":[0.9975008,0.0001918638,0.0007540596,0.0008310627,0.00025742,0.0004648145],"domain_scores_gemma":[0.9980165,0.0005233591,0.0004376016,0.0008378808,0.00005944955,0.0001252139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007979812,0.0002016744,0.00007496265,0.1868546,0.0006279166,0.000004349681,0.000006947054,1.324972e-8,7.243733e-8,0.0006033711,0.0488132,0.7628049],"study_design_scores_gemma":[0.0007027523,0.00008555516,0.00002356813,0.05847989,0.009281565,6.855072e-7,0.000002804177,0.000001313731,0.000001809736,0.0001253676,0.9309025,0.0003921696],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008058629,0.9877365,0.00002886804,0.0005070121,0.0005632885,0.008402908,0.0002717301,0.00006869197,0.002412909],"genre_scores_gemma":[0.000004098804,0.9782537,0.0009575713,0.002753844,0.0002841541,0.001752052,0.001732437,0.00006771614,0.01419447],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8820893,"threshold_uncertainty_score":0.9997191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158178030519843,"score_gpt":0.3209634593432635,"score_spread":0.3051456562912792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}