{"id":"W4409788200","doi":"10.1101/2025.04.23.25324774","title":"Lack of association between <i>G6PD</i> variants and Parkinson’s disease","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University","funders":"National Institutes of Health; Verily Life Sciences; Compute Canada; McGill University; Pfizer; Canada First Research Excellence Fund; Celgene; National Institute of Neurological Disorders and Stroke; Sanofi; Michael J. Fox Foundation for Parkinson's Research; Foundation for the National Institutes of Health","keywords":"Parkinson's disease; Association (psychology); Disease; Genetic association; Medicine; Genetics; Biology; Internal medicine; Psychology; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00361118,0.0004751398,0.000981912,0.000851349,0.0004544775,0.001279624,0.0005689966,0.0006208689,0.003929606],"category_scores_gemma":[0.00585652,0.0002369572,0.002272125,0.001394851,0.0004995648,0.0003738507,0.0004885063,0.0005064928,0.0002580901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002028368,"about_ca_system_score_gemma":0.0002943419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003516409,"about_ca_topic_score_gemma":0.002999475,"domain_scores_codex":[0.99763,0.0006938783,0.0003432813,0.0009082202,0.0003000049,0.0001245967],"domain_scores_gemma":[0.994941,0.002416337,0.001165162,0.0008212827,0.0004104904,0.0002457601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008741076,0.00005603459,0.936238,0.0007450705,0.02692175,0.0007176865,0.0001410783,0.0007650775,0.01042482,0.0003518593,0.001260728,0.01363683],"study_design_scores_gemma":[0.000332371,0.0007642349,0.9657322,0.0001802498,0.0225855,0.001550905,0.0001635625,0.001357168,0.002028799,0.0009989294,0.004286824,0.00001925042],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752525,0.015613,0.002742564,0.0008518032,0.0001896606,0.00002292376,0.002999054,0.00006844535,0.002260156],"genre_scores_gemma":[0.9982975,0.00054254,0.0002505106,0.0001098668,0.00005412844,0.00000562621,0.0004900458,0.00001269493,0.000237053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003929606,"threshold_uncertainty_score":0.01909798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03361837083489105,"score_gpt":0.3284526608818063,"score_spread":0.2948342900469152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}