{"id":"W4409791425","doi":"10.1016/j.ajo.2025.04.022","title":"Ocular Adverse Events Associated with Pegcetacoplan and Avacincaptad Pegol for Geographic Atrophy: A Population-Based Pharmacovigilance Study","year":2025,"lang":"en","type":"article","venue":"American Journal of Ophthalmology","topic":"Drug-Induced Ocular Toxicity","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; Sunnybrook Health Science Centre; Canada Research Chairs; University of Toronto; McMaster University","funders":"","keywords":"Pharmacovigilance; Geographic atrophy; Medicine; Population; Adverse effect; Environmental health; Internal medicine; Ophthalmology; Macular degeneration","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004145458,0.0002290971,0.0008422352,0.0004567193,0.0001107234,0.000005983653,0.0001506419,0.0000594925,0.00001880107],"category_scores_gemma":[0.0003168808,0.0001858742,0.0001862722,0.0005206872,0.000157214,0.00007899039,0.00002576371,0.0003470678,8.342956e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013961,"about_ca_system_score_gemma":0.0003118011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001208879,"about_ca_topic_score_gemma":0.000005127975,"domain_scores_codex":[0.9983049,0.0002914024,0.000501251,0.0002862921,0.0002980661,0.0003181109],"domain_scores_gemma":[0.9982727,0.0002782166,0.0006903063,0.0002225787,0.0003570177,0.0001791661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001438906,0.0007060455,0.9928554,0.00003301975,0.0009782778,0.002137756,0.00006532592,0.0002531983,0.0009077428,0.000005012242,0.000007821844,0.000611519],"study_design_scores_gemma":[0.007627103,0.005106877,0.9816653,0.0001706294,0.0009217648,0.003374967,0.0004319765,0.0003541243,0.0001226166,0.00004296664,0.00001921943,0.0001624324],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979055,0.0001047791,0.0004840892,0.000488703,0.0001573403,0.0007357064,0.00001548538,0.00001535314,0.00009303404],"genre_scores_gemma":[0.9979116,0.000003477489,0.001646547,0.0002346669,0.00005328698,0.00002365001,0.00001792936,0.00002685532,0.00008200289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01119005,"threshold_uncertainty_score":0.757973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312191082623221,"score_gpt":0.3197062149111725,"score_spread":0.3065843040849403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}