{"id":"W4409798211","doi":"10.1016/j.jtct.2025.03.011","title":"Cytokine Release Syndrome and Neurotoxicity Following CD19 CAR-T in B-Cell Lymphoma","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"Cytokine release syndrome; CD19; Neurotoxicity; Lymphoma; Cytokine; Immunology; Medicine; Cancer research; T cell; Antigen; Chimeric antigen receptor; Internal medicine; Toxicity; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005546049,0.0006593154,0.0005410064,0.0007286546,0.0004608336,0.0003623673,0.0004946679,0.001229159,0.001361738],"category_scores_gemma":[0.001249133,0.000288473,0.0004921272,0.0004479213,0.000736158,0.0005711463,0.0004195261,0.00136081,0.0003389272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005878253,"about_ca_system_score_gemma":0.0004024996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222084,"about_ca_topic_score_gemma":0.001202327,"domain_scores_codex":[0.9997178,0.0001061594,0.00003241593,0.00002583871,0.00003928493,0.00007841652],"domain_scores_gemma":[0.999248,0.000303855,0.0001893395,0.00008485391,0.00006668091,0.0001072505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.03511907,0.002415875,0.1143934,0.0007704269,0.0005747663,0.6316112,0.0007597795,0.001328082,0.1660666,0.002228492,0.001543109,0.04318923],"study_design_scores_gemma":[0.001787817,0.01764071,0.3317154,0.0001164632,0.001065281,0.5283346,0.0009305172,0.003874057,0.1061903,0.002904054,0.005345623,0.00009515582],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928499,0.002146994,0.001193543,0.0002187143,0.00004468284,0.00005395437,0.00008908815,0.00004755847,0.003355408],"genre_scores_gemma":[0.9990085,0.0003587371,0.00009588065,0.00008668573,0.0000413466,0.00001386036,0.00007131873,0.000003961655,0.000319703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361738,"threshold_uncertainty_score":0.004555404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477724531688359,"score_gpt":0.2716196132885174,"score_spread":0.2568423679716338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}