{"id":"W4409798211","doi":"10.1016/j.jtct.2025.03.011","title":"Cytokine Release Syndrome and Neurotoxicity Following CD19 CAR-T in B-Cell Lymphoma","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"Cytokine release syndrome; CD19; Neurotoxicity; Lymphoma; Cytokine; Immunology; Medicine; Cancer research; T cell; Antigen; Chimeric antigen receptor; Internal medicine; Toxicity; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002450942,0.0001692807,0.0002879934,0.0002535101,0.00007815616,0.00003304574,0.00005708414,0.0001001741,0.0001314504],"category_scores_gemma":[0.000003999107,0.0001574086,0.00007875404,0.0003019386,0.00005770049,0.00007293193,0.000006976079,0.0001538873,0.000003960175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003707342,"about_ca_system_score_gemma":0.0000674258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000177029,"about_ca_topic_score_gemma":0.00002739304,"domain_scores_codex":[0.9988772,0.0001117391,0.0002379611,0.0003220495,0.0002132539,0.0002377719],"domain_scores_gemma":[0.9995773,0.00008572263,0.00002577402,0.0001778395,0.00002135302,0.0001119979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001647363,0.0002884795,0.02057507,0.0002919041,0.00005940121,0.001240387,0.0008543532,0.000003129174,0.953839,0.00009216862,0.000008717126,0.0211],"study_design_scores_gemma":[0.04135805,0.0008122021,0.1618972,0.0003931832,0.0001385265,0.00038569,0.00031232,0.00103367,0.7879434,0.0003151278,0.004994617,0.0004160588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942961,0.001890164,0.0004508481,0.0004078463,0.00006789664,0.0007100001,0.000008697171,0.00004562362,0.002122772],"genre_scores_gemma":[0.9896725,0.006863708,0.00007012315,0.0006641983,0.00001445736,0.00003618979,0.00004928606,0.00002198113,0.002607501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1658957,"threshold_uncertainty_score":0.6418936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477724531688359,"score_gpt":0.2716196132885174,"score_spread":0.2568423679716338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}