{"id":"W4409799760","doi":"10.1016/j.carres.2025.109502","title":"Carbohydrate sulfation as a critical modulator of siglec-sialoglycan interactions","year":2025,"lang":"en","type":"review","venue":"Carbohydrate Research","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Glycomics Network; Canadian Institutes of Health Research; Canada Excellence Research Chairs, Government of Canada; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Sulfation; SIGLEC; Carbohydrate; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174577,0.0005494522,0.000602093,0.001227489,0.0001934663,0.0007861032,0.0003679663,0.0005554246,0.00287411],"category_scores_gemma":[0.0002743547,0.0001817268,0.0002587139,0.001467315,0.0001783201,0.0007951486,0.0004158689,0.000858784,0.001932323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004693486,"about_ca_system_score_gemma":0.0007359234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006520974,"about_ca_topic_score_gemma":0.0009495821,"domain_scores_codex":[0.9999157,0.00001185408,0.000008880139,0.00001591236,0.00003436512,0.00001330384],"domain_scores_gemma":[0.9999228,0.00002324381,0.00001134349,0.000002603556,0.000028137,0.00001195719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001328317,0.00005635166,0.0003302556,0.01398673,0.00008400458,0.0003056804,0.00007826534,0.0004986041,0.01512893,0.00588133,0.02234052,0.9411766],"study_design_scores_gemma":[0.00001015528,0.00009286361,0.0008370799,0.001317952,0.00009638861,0.0008712226,0.00005914333,0.000136378,0.004393267,0.001491029,0.9906762,0.00001836546],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000742859,0.9958349,0.0002981674,0.0002667003,0.0002049698,0.000005409044,0.00005389105,0.00001660038,0.002576444],"genre_scores_gemma":[0.002544811,0.9955617,0.0002854799,0.0001370961,0.00008312264,0.000006650753,0.00007294994,0.000002022157,0.00130613],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00287411,"threshold_uncertainty_score":0.009614825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08883122511770024,"score_gpt":0.4728052317019709,"score_spread":0.3839740065842707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}