{"id":"W4409802934","doi":"10.1101/2025.04.24.650438","title":"Elevated GLUT4 Levels in Human Skeletal Muscle Microtissues is Accompanied by Functional Insulin Dependence","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"Canada First Research Excellence Fund; Canada Research Chairs","keywords":"GLUT4; Skeletal muscle; Insulin; Human insulin; Internal medicine; Endocrinology; Cell biology; Chemistry; Biology; Medicine; Glucose uptake","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000218199,0.000229042,0.0001991131,0.0002452355,0.0001856359,0.000333113,0.0001239991,0.0002252035,0.003159887],"category_scores_gemma":[0.0001597656,0.0001810745,0.0002157226,0.0002582181,0.0001864319,0.0001669868,0.0002901869,0.0003708316,0.0006865076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001649418,"about_ca_system_score_gemma":0.00009006216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006009864,"about_ca_topic_score_gemma":0.0005374884,"domain_scores_codex":[0.9998158,0.000024044,0.00002178455,0.00005881111,0.00004792823,0.00003164801],"domain_scores_gemma":[0.9998796,0.00001979949,0.00003045891,0.00002149973,0.00002628568,0.00002218485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002968135,0.00002787128,0.002396395,0.0000458362,0.00001711265,0.00009233983,0.00003954336,0.00003805264,0.995437,0.00003287138,0.00007557516,0.001500598],"study_design_scores_gemma":[0.00003115715,0.0008330105,0.1717293,0.00002112392,0.00005929041,0.001507339,0.0003144665,0.001110704,0.8203777,0.000141128,0.003860906,0.00001390212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935551,0.001497118,0.00283323,0.00009914527,0.00003070706,0.00002147994,0.0005738731,0.00007267977,0.001316698],"genre_scores_gemma":[0.9946137,0.0004902055,0.001440169,0.00008361574,0.000009264908,0.00006159415,0.000970643,0.00002276525,0.002307985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003159887,"threshold_uncertainty_score":0.01057082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521867895033389,"score_gpt":0.2425619544697293,"score_spread":0.2273432755193955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}