{"id":"W4409803860","doi":"10.1002/advs.202411667","title":"hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Liver physiology and pathology","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Science Foundation of Beijing Municipality; Tsinghua University; National Natural Science Foundation of China","keywords":"Organoid; Cell biology; Biology; Hepatic stellate cell; Embryonic stem cell; Hepatocyte; Liver cytology; In vitro; Endocrinology; Biochemistry; Liver metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001454686,0.00009114854,0.0001391953,0.0001020247,0.00026426,0.000009151046,0.00014553,0.00007514636,0.00004518123],"category_scores_gemma":[0.0002037755,0.00007583613,0.00002926975,0.000662293,0.000526253,0.000439402,0.00006435291,0.0001610194,0.00003825445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006909962,"about_ca_system_score_gemma":0.0001679727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001128022,"about_ca_topic_score_gemma":0.000008544665,"domain_scores_codex":[0.9991418,0.00003254302,0.0001116495,0.000348435,0.0001587993,0.0002068276],"domain_scores_gemma":[0.9994326,0.00006362836,0.00004701696,0.0002510151,0.0001693935,0.00003633331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001406585,0.00005120558,0.001271949,0.00001958914,0.000007426353,0.00001061941,0.0008443633,0.0003764685,0.9606209,0.02309993,0.0001097573,0.01344712],"study_design_scores_gemma":[0.0007847802,0.0002141563,0.7858987,0.00004586863,0.00002430182,0.00002522255,0.00012661,0.0009332307,0.19563,0.01524288,0.0009621595,0.0001121607],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723523,0.0002185652,0.01232231,0.001271794,0.0005257138,0.0002596432,0.00000273322,0.00007586471,0.01297104],"genre_scores_gemma":[0.9871958,0.0000549844,0.008441893,0.001863958,0.00003938012,0.00001017971,0.00001416392,0.000003960961,0.002375609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7846267,"threshold_uncertainty_score":0.3092508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130430609457131,"score_gpt":0.3054195377152937,"score_spread":0.2941152316207225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}