{"id":"W4409803860","doi":"10.1002/advs.202411667","title":"hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Liver physiology and pathology","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Science Foundation of Beijing Municipality; Tsinghua University; National Natural Science Foundation of China","keywords":"Organoid; Cell biology; Biology; Hepatic stellate cell; Embryonic stem cell; Hepatocyte; Liver cytology; In vitro; Endocrinology; Biochemistry; Liver metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001826733,0.0002934288,0.0001501204,0.0002046288,0.0001099141,0.0003512047,0.0001128914,0.0003097981,0.001081949],"category_scores_gemma":[0.0001185243,0.0001305257,0.0002311258,0.0001139733,0.0002305674,0.0002574143,0.0003212928,0.0004712626,0.0003277271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675647,"about_ca_system_score_gemma":0.0001381014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003242998,"about_ca_topic_score_gemma":0.0007018406,"domain_scores_codex":[0.9999124,0.00001293905,0.000009779344,0.0000209647,0.00002786572,0.00001608394],"domain_scores_gemma":[0.9998981,0.00002013033,0.00002979567,0.00001669134,0.00001588869,0.00001947968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003894524,0.000008605818,0.0001780048,0.00005436804,0.00000497992,0.00007238444,0.00003718598,0.0003709619,0.9971284,0.0002716821,0.00005647955,0.001777978],"study_design_scores_gemma":[0.000005484784,0.00007663859,0.001146242,0.000007076938,0.00001107932,0.0001443146,0.00004183004,0.001013966,0.9919173,0.00005736688,0.005573036,0.000005675871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438302,0.002552754,0.0459504,0.0001582983,0.0001388346,0.0001348464,0.0009257941,0.0004445301,0.00586426],"genre_scores_gemma":[0.9835131,0.001027547,0.01143621,0.00006053032,0.000008937134,0.00008040606,0.0004277218,0.00004757246,0.003398029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001081949,"threshold_uncertainty_score":0.003619432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130430609457131,"score_gpt":0.3054195377152937,"score_spread":0.2941152316207225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}