{"id":"W4409804826","doi":"10.1002/pro.70144","title":"N‐terminomics and proteomics analysis of Calpain‐2 reveal key proteolytic processing of metabolic and cell adhesion proteins","year":2025,"lang":"en","type":"article","venue":"Protein Science","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Australian Government","keywords":"Calpain; Proteases; Proteomics; Biochemistry; Proteolysis; Chemistry; Protease; Cell biology; Biology; Cysteine protease; Proteome; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007911803,0.0001284898,0.0002559321,0.0003743199,0.0001483182,0.00003517751,0.000160317,0.0000979852,0.000002265024],"category_scores_gemma":[0.0002225659,0.0001111195,0.00005932548,0.001073248,0.0006692938,0.0000202534,0.0001848115,0.0000679342,1.337646e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001121887,"about_ca_system_score_gemma":0.0002779002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003777403,"about_ca_topic_score_gemma":0.000009272977,"domain_scores_codex":[0.9987828,0.0000570317,0.0003346223,0.0004395949,0.0002087644,0.0001771438],"domain_scores_gemma":[0.9991521,0.000006732248,0.0002525451,0.0002734585,0.0002438279,0.00007130812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008619085,0.00004825562,0.005528278,0.0002553553,0.00002790477,1.598587e-7,0.00009092137,0.00005111046,0.9865503,0.0003013836,0.000002227267,0.007057874],"study_design_scores_gemma":[0.0003255724,0.0001210914,0.0260868,0.00007902108,0.0001303814,0.000001380648,0.0000502714,0.005972155,0.9667435,0.0001801424,0.0001964119,0.0001133272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834371,0.001129557,0.01355469,0.00008598828,0.00001804593,0.001538408,0.000007364592,0.000006663151,0.0002221938],"genre_scores_gemma":[0.9872853,0.00003649666,0.01194566,0.00002724287,0.00001468286,0.0001321998,0.000005915471,0.00000577347,0.0005466962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02055852,"threshold_uncertainty_score":0.4531323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00585252575911125,"score_gpt":0.2415300623933991,"score_spread":0.2356775366342878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}