{"id":"W4409804826","doi":"10.1002/pro.70144","title":"N‐terminomics and proteomics analysis of Calpain‐2 reveal key proteolytic processing of metabolic and cell adhesion proteins","year":2025,"lang":"en","type":"article","venue":"Protein Science","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Australian Government","keywords":"Calpain; Proteases; Proteomics; Biochemistry; Proteolysis; Chemistry; Protease; Cell biology; Biology; Cysteine protease; Proteome; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002988293,0.0005699959,0.0002447788,0.0005553098,0.000255237,0.0005179474,0.0002519623,0.0003646903,0.0006205864],"category_scores_gemma":[0.0003616613,0.0001918296,0.0003513426,0.0004124681,0.0002433136,0.0003651917,0.0002394233,0.0006566744,0.000271324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003917668,"about_ca_system_score_gemma":0.0003329507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007962674,"about_ca_topic_score_gemma":0.001615188,"domain_scores_codex":[0.999805,0.00001944364,0.00001094417,0.0000561889,0.00007954812,0.00002886041],"domain_scores_gemma":[0.9998434,0.00002753135,0.00004446834,0.00002224935,0.00003696256,0.00002537676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004912342,0.000006763407,0.0004889409,0.00002090971,0.000006885598,0.0000536265,0.00001063649,0.00003111901,0.9983633,0.00004354593,0.00003175012,0.0008934094],"study_design_scores_gemma":[0.00001131886,0.0001017474,0.03008969,0.000008803272,0.00003253406,0.0008375255,0.00004514999,0.001532164,0.9650435,0.0001869581,0.002100419,0.00001021269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669977,0.004967294,0.02421007,0.0002480739,0.0000558592,0.00006139358,0.001905998,0.0001234579,0.001430055],"genre_scores_gemma":[0.926317,0.004723285,0.06054959,0.0004378268,0.00006752956,0.00008304685,0.003867114,0.00009053058,0.003864154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007962674,"threshold_uncertainty_score":0.002842486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00585252575911125,"score_gpt":0.2415300623933991,"score_spread":0.2356775366342878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}