{"id":"W4409805923","doi":"10.1002/chem.202500993","title":"Lewis‐X‐Containing Triterpenoid Saponins Inhibit DC‐SIGN‐ and L‐SIGN‐Mediated Transfer of HIV‐1 Infection","year":2025,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Institut National de la Recherche Scientifique; Université du Québec à Chicoutimi","funders":"Armand-Frappier Foundation; Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"DC-SIGN; Glycosylation; Chemistry; Human immunodeficiency virus (HIV); Fucose; Stereochemistry; Immune system; Biochemistry; Immunology; Biology; Galactose","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005618925,0.0002745319,0.0001137208,0.0001488508,0.00005934398,0.0001231035,0.0001055719,0.000107129,0.0009770492],"category_scores_gemma":[0.00007081105,0.00005243851,0.0001140924,0.00009626246,0.000134828,0.000131432,0.0001150751,0.0002232001,0.000298177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001080463,"about_ca_system_score_gemma":0.0001267606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001758928,"about_ca_topic_score_gemma":0.0003904231,"domain_scores_codex":[0.9999725,0.000004482924,0.000002402375,0.00000321523,0.000006978119,0.00001043631],"domain_scores_gemma":[0.9999655,0.000006882831,0.000008464363,0.000004297605,0.000003314329,0.00001145847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008099938,0.00002165785,0.00005201054,0.00002684475,0.000004845976,0.00003742369,0.000007510643,0.0002183464,0.9971813,0.00008996434,0.00003717565,0.002241958],"study_design_scores_gemma":[0.00001225624,0.0002486212,0.0005511033,0.00000290701,0.000005495426,0.00007425741,0.000007377259,0.0004877097,0.9977593,0.00002672392,0.000821957,0.000002229917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941215,0.001061945,0.00250774,0.00003490999,0.00001533439,0.00002673728,0.0001600952,0.00005753971,0.002014142],"genre_scores_gemma":[0.9951804,0.0009623221,0.001605542,0.00003110463,0.000004588489,0.00001591761,0.0001847368,0.00001081001,0.002004546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009770492,"threshold_uncertainty_score":0.00326854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217333309352596,"score_gpt":0.2134829338188385,"score_spread":0.2013096007253125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}