{"id":"W4409816471","doi":"10.1016/j.toxrep.2025.102039","title":"Safety toxicology of an IL-2 ‘no-alpha’ mutein in the Sprague-Dawley rat following repeated dosing via intravenous administration","year":2025,"lang":"en","type":"article","venue":"Toxicology Reports","topic":"Immunotoxicology and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Nucro Technics","funders":"","keywords":"Dosing; Pharmacology; Alpha (finance); Medicine; Chemistry; Toxicology; Biology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.003254022,0.0004481931,0.001035937,0.0005290738,0.0004971008,0.00002624049,0.0005689619,0.001380025,0.0003662789],"category_scores_gemma":[0.001305292,0.0003807136,0.0002805832,0.0006964873,0.0007894785,0.0002656108,0.0001745556,0.001060262,0.00005951327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835649,"about_ca_system_score_gemma":0.000804348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001569888,"about_ca_topic_score_gemma":0.0005300383,"domain_scores_codex":[0.9933615,0.002924361,0.001938054,0.0008115502,0.00008972106,0.0008748301],"domain_scores_gemma":[0.9967645,0.001089656,0.0007574832,0.00119483,0.0001617307,0.00003173226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002982185,0.001397205,0.004911334,0.00003864434,0.0004205675,0.001943979,0.0009601373,0.00001977598,0.9773542,0.0006884718,0.0007452207,0.008538288],"study_design_scores_gemma":[0.003677062,0.004334552,0.08744459,0.0001684401,0.0003751378,0.006664949,0.00100987,0.00002767315,0.8655975,0.001398496,0.02865963,0.0006421222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860478,0.002202667,0.0002731128,0.0009284974,0.005393319,0.001194002,0.00000801516,0.0001251035,0.003827455],"genre_scores_gemma":[0.996199,0.00006357899,0.0001545345,0.001023557,0.00003928083,0.0001510364,0.0002420421,0.00002797169,0.002098977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1117567,"threshold_uncertainty_score":0.9999164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00800473945829553,"score_gpt":0.2676598808889683,"score_spread":0.2596551414306728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}