{"id":"W4409819409","doi":"10.1002/alz.70152","title":"Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chief Scientist Office, Scottish Government Health and Social Care Directorate; UK Dementia Research Institute; Siemens Healthineers; Fondation Leducq; Consejo Nacional de Ciencia y Tecnología; Wellcome Trust; Alzheimer's Society; Dunhill Medical Trust; University of Edinburgh; Stroke Association; Scottish Funding Council; UK Research and Innovation; Alzheimer Society; Edinburgh and Lothians Health Foundation; Medical Research Council; Scottish Government Health and Social Care Directorate; British Heart Foundation","keywords":"Medicine; Biomarker; Neuroimaging; Magnetic resonance imaging; Endothelial dysfunction; Platelet activation; Pathology; Cognitive decline; Stroke (engine); Platelet; Internal medicine; Disease; Radiology; Dementia; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001632039,0.0003190271,0.0003265407,0.0005544897,0.0003257683,0.0006942436,0.0002454902,0.0004372808,0.000840406],"category_scores_gemma":[0.002391424,0.0001841702,0.0004463496,0.0007004988,0.0001989855,0.0003340763,0.0003548438,0.0004351937,0.0001433796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002357698,"about_ca_system_score_gemma":0.0004338149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002729671,"about_ca_topic_score_gemma":0.00362828,"domain_scores_codex":[0.9997039,0.0001324514,0.00002372155,0.00006736182,0.00003796927,0.00003452015],"domain_scores_gemma":[0.9983445,0.0002784869,0.0007820033,0.0001669933,0.0002231902,0.0002047731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00029712,0.00006485252,0.9947731,0.00002218132,0.0002421614,0.00007723655,0.00007622913,0.00007041917,0.0006306972,0.00003353859,0.0001008088,0.003611653],"study_design_scores_gemma":[0.00001218006,0.0001620803,0.9987287,0.00001182615,0.0001264519,0.0001749655,0.00004630282,0.0001701778,0.0001722971,0.0001143121,0.000275351,0.0000053143],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978845,0.0009650929,0.0002712432,0.0001160963,0.000006891891,0.000007353626,0.0004555538,0.000004667416,0.0002885819],"genre_scores_gemma":[0.9984943,0.0004017298,0.0004031504,0.0000488338,0.00002034259,0.00001461145,0.0004699295,0.000001925918,0.0001452732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002729671,"threshold_uncertainty_score":0.00863111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03097838341879873,"score_gpt":0.2760315946444945,"score_spread":0.2450532112256958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}