{"id":"W4409820850","doi":"10.1158/1538-7445.am2025-lb397","title":"Abstract LB397: Biomarker-guided dose selection in the iintune-1 study of dazostinag,a STING agonist, alone and in combination with pembrolizumab for patients with metastatic solid tumors","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Pembrolizumab; Medicine; Sting; Oncology; Internal medicine; Biomarker; Agonist; Cancer; Immunotherapy; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009772242,0.0007883384,0.001064457,0.0002845942,0.000245936,0.0008738692,0.0004626761,0.0006593563,0.002143508],"category_scores_gemma":[0.0006413183,0.0003602667,0.0007449534,0.0002808467,0.0004522895,0.000476267,0.0002909112,0.00187134,0.0005145665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008766864,"about_ca_system_score_gemma":0.001135229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005761058,"about_ca_topic_score_gemma":0.002011831,"domain_scores_codex":[0.9996926,0.0001402708,0.00001965684,0.00005683942,0.00003895816,0.00005176413],"domain_scores_gemma":[0.9996877,0.00004601341,0.0000838473,0.00002658056,0.00002255392,0.0001333441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5496181,0.05961619,0.01829441,0.0006074444,0.000992084,0.0002643083,0.0004912413,0.005525759,0.2070633,0.0003455611,0.002929228,0.1542523],"study_design_scores_gemma":[0.1456483,0.7910051,0.03287968,0.00005589467,0.0006527195,0.0003911698,0.0001095465,0.002987937,0.02128201,0.0002376964,0.004705327,0.00004465441],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964074,0.0009083416,0.0002949994,0.0001808067,0.00003108278,0.00086874,0.0003805165,0.00004178746,0.0008862293],"genre_scores_gemma":[0.9958334,0.0004291352,0.0009927028,0.0001959976,0.00003561402,0.0006759265,0.0005694269,0.00001225166,0.001255477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002143508,"threshold_uncertainty_score":0.007170737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05624023280462687,"score_gpt":0.3924653150882246,"score_spread":0.3362250822835978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}