{"id":"W4409821598","doi":"10.1158/1538-7445.am2025-ct262","title":"Abstract CT262: Efficacy and safety of the combination PKMYT1-inhibitor lunresertib and ATR-inhibitor camonsertib in patients with ovarian and endometrial cancers: Phase I MYTHIC study (NCT04855656)","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Concordia University; McGill University","funders":"","keywords":"Medicine; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007668472,0.0006049437,0.0008957232,0.0002623421,0.0002255808,0.0005992691,0.0004669237,0.0004542992,0.00621993],"category_scores_gemma":[0.0005411985,0.0002461545,0.000763623,0.0003634794,0.0003038928,0.0003548976,0.0002395203,0.001442202,0.0009166162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006946622,"about_ca_system_score_gemma":0.0009685858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141038,"about_ca_topic_score_gemma":0.003016808,"domain_scores_codex":[0.9997142,0.00013484,0.0000158539,0.00004952229,0.00004353442,0.00004207939],"domain_scores_gemma":[0.9997371,0.00003396338,0.00007595522,0.00002482583,0.00002559305,0.0001025536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6568849,0.01459328,0.02846671,0.00130303,0.002749556,0.0004012585,0.0001765627,0.005460049,0.124546,0.0003586194,0.01568245,0.1493776],"study_design_scores_gemma":[0.3113448,0.5306107,0.1038032,0.0001473415,0.002801724,0.001941868,0.0001146278,0.004366603,0.02681203,0.0002791428,0.0177055,0.00007251403],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876876,0.003460288,0.0003852692,0.0002510883,0.00004189189,0.000551788,0.003126055,0.0001374513,0.004358571],"genre_scores_gemma":[0.9892237,0.0009573338,0.000714016,0.0003132493,0.00007259448,0.0003760274,0.005565115,0.00003412483,0.002743724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00621993,"threshold_uncertainty_score":0.02080774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03083242900058225,"score_gpt":0.3785195236069916,"score_spread":0.3476870946064093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}