{"id":"W4409821598","doi":"10.1158/1538-7445.am2025-ct262","title":"Abstract CT262: Efficacy and safety of the combination PKMYT1-inhibitor lunresertib and ATR-inhibitor camonsertib in patients with ovarian and endometrial cancers: Phase I MYTHIC study (NCT04855656)","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Concordia University; McGill University","funders":"","keywords":"Medicine; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001128349,0.0001842327,0.0004296704,0.000481054,0.0002290124,0.00005698763,0.0001177957,0.0001010373,0.00005750925],"category_scores_gemma":[0.0002912988,0.0001258905,0.0000309095,0.001098385,0.0002983536,0.0001131201,0.0001404087,0.0005615515,2.760795e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004568124,"about_ca_system_score_gemma":0.0007393946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004234299,"about_ca_topic_score_gemma":0.002525012,"domain_scores_codex":[0.9978213,0.0002265513,0.0003785727,0.0004788999,0.0007312159,0.0003634858],"domain_scores_gemma":[0.9986795,0.0003677135,0.00009576057,0.0003586973,0.0003533297,0.0001450124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0874966,0.004178722,0.76965,0.0009542288,0.0006283253,0.00003540558,0.005338768,0.00001329809,0.03629792,0.0006487939,0.0007321881,0.09402578],"study_design_scores_gemma":[0.07913645,0.003573361,0.904271,0.00113394,0.00007184885,0.000001126628,0.0007782676,0.00004391385,0.01020738,0.0001260336,0.0005041888,0.0001525139],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935081,0.001646679,0.000006918408,0.001153219,0.0002630949,0.003232248,0.00004361519,0.00001233981,0.00013381],"genre_scores_gemma":[0.9990914,0.0003366474,0.00001477752,0.00006930555,0.000110942,0.0001622266,0.000005677167,0.000023594,0.0001853779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.134621,"threshold_uncertainty_score":0.6401022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03083242900058225,"score_gpt":0.3785195236069916,"score_spread":0.3476870946064093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}