{"id":"W4409821785","doi":"10.1158/1538-7445.am2025-ct239","title":"Abstract CT239: IND.241: A Canadian cancer trials group liquid-biopsy informed platform trial to evaluate treatment in CDK4/6-inhibitor resistant ER+/HER2- metastatic breast cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Society for Arts and Technology; Hamilton Health Sciences; Queen's University; Juravinski Cancer Centre; Sunnybrook Health Science Centre; Ottawa Hospital; Princess Margaret Cancer Centre; Interior Health; Queen Elizabeth II Health Sciences Centre; Kingston Health Sciences Centre","funders":"","keywords":"Medicine; Metastatic breast cancer; Cancer; Oncology; Breast cancer; Internal medicine; Clinical trial; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00128883,0.00119715,0.001001767,0.0002417672,0.0008126271,0.0007768902,0.001229326,0.001123013,0.0150299],"category_scores_gemma":[0.001232437,0.0002425798,0.0007554179,0.0005120191,0.0007671144,0.0003565363,0.0003074384,0.002542992,0.00148702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005699732,"about_ca_system_score_gemma":0.01278814,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.114572,"about_ca_topic_score_gemma":0.3188379,"domain_scores_codex":[0.9994178,0.0002580571,0.00001501694,0.00007681875,0.0001220036,0.0001103202],"domain_scores_gemma":[0.999255,0.00007212891,0.0001002457,0.00004080117,0.00008604099,0.0004457403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8132596,0.01042645,0.004847773,0.001020364,0.00157526,0.0001891841,0.0001294708,0.002152531,0.01001293,0.00127058,0.06627343,0.08884251],"study_design_scores_gemma":[0.8384513,0.09541377,0.03741635,0.0002165881,0.001124156,0.0001496164,0.00007964245,0.001874181,0.001702449,0.0008855016,0.02260605,0.00008036612],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8640607,0.008093228,0.0009695878,0.01085118,0.0006560246,0.01634225,0.04516773,0.000325446,0.05353385],"genre_scores_gemma":[0.9412075,0.00294809,0.003199812,0.005568131,0.000410269,0.006326432,0.01844855,0.00006662909,0.02182459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.885428,"threshold_uncertainty_score":0.2278103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1613554847893687,"score_gpt":0.4902675803125865,"score_spread":0.3289120955232178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}