{"id":"W4409821972","doi":"10.1158/1538-7445.am2025-ct157","title":"Abstract CT157: Phase 1 dose-escalation study of linclatamig, a LY6G6D×CD3 T cell-engaging bispecific antibody, in patients with colorectal cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Bispecific antibody; Medicine; Colorectal cancer; Antibody; Oncology; Internal medicine; Cancer; Cancer research; Monoclonal antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004525505,0.001016435,0.00125633,0.0003230972,0.0003518246,0.0006637138,0.0004676914,0.0007225255,0.004348881],"category_scores_gemma":[0.0004880101,0.0003676363,0.0006665279,0.0003673009,0.0005246919,0.0004440397,0.0002678541,0.002321618,0.001138126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047049,"about_ca_system_score_gemma":0.001505574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154298,"about_ca_topic_score_gemma":0.002580419,"domain_scores_codex":[0.9998277,0.0000547431,0.00001117136,0.00004396064,0.00002315737,0.00003916894],"domain_scores_gemma":[0.9997254,0.00002814715,0.0000490594,0.00001802684,0.00002424194,0.000155089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.591454,0.06739655,0.01857152,0.00125773,0.0009998728,0.0006331498,0.0003572547,0.004189681,0.1736286,0.0003724395,0.008381907,0.1327574],"study_design_scores_gemma":[0.1967006,0.7589217,0.02503018,0.00005163751,0.0003485318,0.0005491589,0.00007071674,0.001394755,0.01130458,0.0001105965,0.005487377,0.00003010105],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937831,0.001150104,0.0004055471,0.0002222545,0.0000628941,0.001654315,0.001015291,0.00009253759,0.001614037],"genre_scores_gemma":[0.9887299,0.0009286879,0.001209807,0.0005220946,0.00007679876,0.002088498,0.002552469,0.00002289312,0.003868841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004348881,"threshold_uncertainty_score":0.01454842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05752751205684187,"score_gpt":0.4536311384396099,"score_spread":0.396103626382768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}