{"id":"W4409822021","doi":"10.1158/1538-7445.am2025-ct198","title":"Abstract CT198: A first-in-human study evaluating safety, tolerability and efficacy of TEV-56278, as monotherapy and in combination with pembrolizumab in participants with locally advanced or metastatic solid tumors","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pembrolizumab; Tolerability; Medicine; Oncology; Solid tumor; Internal medicine; Response Evaluation Criteria in Solid Tumors; Medical physics; Adverse effect; Cancer; Clinical trial; Immunotherapy; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002227926,0.001889503,0.001799108,0.0004296624,0.0008633207,0.0009992246,0.0008360362,0.001646437,0.007785254],"category_scores_gemma":[0.0009741079,0.000643115,0.001127882,0.0004029914,0.001373366,0.001240271,0.0003611947,0.003253714,0.00210938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001310928,"about_ca_system_score_gemma":0.002095091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211848,"about_ca_topic_score_gemma":0.002610123,"domain_scores_codex":[0.9992624,0.0003267368,0.00003537714,0.0001434895,0.00008611788,0.0001459241],"domain_scores_gemma":[0.9988128,0.0001688577,0.0002178439,0.0001100353,0.0001131089,0.0005772853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6895039,0.125567,0.006515011,0.0007387358,0.0009492995,0.0003576401,0.0003722779,0.0009511932,0.1243745,0.0001810426,0.004456847,0.0460326],"study_design_scores_gemma":[0.1166706,0.8610722,0.01034685,0.00002295595,0.0003696863,0.0002280429,0.00007230748,0.0003913732,0.007897427,0.0001215363,0.002779245,0.00002763392],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881677,0.001011541,0.001173614,0.0003224353,0.0001179409,0.004489619,0.002763912,0.0001527887,0.001800397],"genre_scores_gemma":[0.9826807,0.0007096092,0.002180399,0.0007767881,0.0002064762,0.004571095,0.002671505,0.00006184333,0.006141501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007785254,"threshold_uncertainty_score":0.02604431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09054043081958066,"score_gpt":0.4737803933891477,"score_spread":0.383239962569567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}