{"id":"W4409822055","doi":"10.1158/1538-7445.am2025-ct148","title":"Abstract CT148: Phase 1 study of the anti-immunoglobulin-like transcript 4 (ILT4) monoclonal antibody MK-4830 plus pembrolizumab plus chemotherapy in patients with advanced solid tumors","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre; University of Ottawa","funders":"","keywords":"Pembrolizumab; Medicine; Monoclonal antibody; Chemotherapy; Antibody; Pharmacokinetics; Internal medicine; Oncology; Cancer research; Pharmacology; Immunotherapy; Cancer; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009371811,0.001629117,0.001507118,0.0004968811,0.0005393311,0.0008425456,0.001079248,0.001233804,0.007519423],"category_scores_gemma":[0.0006899846,0.0005989459,0.0009973424,0.000448738,0.0006790878,0.0006550477,0.0003285316,0.003125553,0.001641485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00133648,"about_ca_system_score_gemma":0.002493285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001920635,"about_ca_topic_score_gemma":0.004561666,"domain_scores_codex":[0.9997348,0.0001179375,0.00001406097,0.00004886132,0.00002714505,0.0000571419],"domain_scores_gemma":[0.9995368,0.00005003107,0.00009686584,0.00003199644,0.00003977376,0.0002446075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7052931,0.09251731,0.01118604,0.001179334,0.001108579,0.0004407619,0.0003090618,0.002684431,0.09781241,0.0003885168,0.01022384,0.07685671],"study_design_scores_gemma":[0.5680904,0.4060845,0.0155892,0.00004904404,0.0003709505,0.0003322224,0.00004842295,0.0009813478,0.004905432,0.0001457192,0.003378098,0.00002466414],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859585,0.00134351,0.000552304,0.0004961182,0.0001289041,0.005498497,0.00284273,0.000183926,0.002995496],"genre_scores_gemma":[0.9815763,0.001129766,0.001964019,0.000844661,0.0001674913,0.005070149,0.004781383,0.00004146531,0.004424735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007519423,"threshold_uncertainty_score":0.02515501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03117471096516407,"score_gpt":0.4027522681327222,"score_spread":0.3715775571675581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}