{"id":"W4409822066","doi":"10.1158/1538-7445.am2025-ct195","title":"Abstract CT195: A phase 1 dose escalation/expansion study of GSK5764227, a B7-homolog 3 protein targeted antibody-drug conjugate, in combination with standard of care in patients with advanced solid tumors","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Antibody-drug conjugate; Conjugate; Standard of care; Medicine; Antibody; Drug; Cancer research; Solid tumor; Cancer; Oncology; Pharmacology; Internal medicine; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001241958,0.002110412,0.001497849,0.0006723955,0.0003748749,0.001020858,0.001248991,0.001050833,0.005682786],"category_scores_gemma":[0.0006295408,0.0005467521,0.001277148,0.0006440719,0.001025408,0.000976535,0.0004380115,0.004588716,0.001371772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001697634,"about_ca_system_score_gemma":0.002132921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001750635,"about_ca_topic_score_gemma":0.00486808,"domain_scores_codex":[0.9996611,0.0001318615,0.00001626144,0.00006998445,0.00005283273,0.00006801757],"domain_scores_gemma":[0.999552,0.00004274914,0.00008079323,0.00002881626,0.00003276065,0.0002628924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5014784,0.1577593,0.01118752,0.001968251,0.002182634,0.0007159834,0.0006670124,0.006738523,0.1459619,0.0009397971,0.01861934,0.1517813],"study_design_scores_gemma":[0.4344176,0.5346953,0.01350154,0.00006199723,0.0005673156,0.0004231946,0.0001105104,0.001716172,0.008371818,0.000215386,0.005871905,0.00004722414],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854015,0.002507974,0.001004358,0.0007416612,0.0001662962,0.00367768,0.002989583,0.0002364978,0.003274425],"genre_scores_gemma":[0.9812462,0.00217057,0.002477132,0.00143655,0.0001425368,0.002544308,0.005704273,0.00006146012,0.004216849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005682786,"threshold_uncertainty_score":0.01901084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269000971195673,"score_gpt":0.4296070132920876,"score_spread":0.4069170035801309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}