{"id":"W4409822130","doi":"10.1158/1538-7445.am2025-ct074","title":"Abstract CT074: Discovery and preliminary clinical findings of MK-6598, a potent and selective inhibitor of the immune checkpoint IL4I1","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Immune system; Pharmacology; Immune checkpoint; Biology; Medicine; Immunology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004867947,0.001258818,0.000651669,0.0004151038,0.0002821696,0.0007488899,0.000598054,0.0008740349,0.002226289],"category_scores_gemma":[0.0004000741,0.0002539224,0.0003949333,0.0002984694,0.0005401766,0.0003781859,0.0002499157,0.002301338,0.001066316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007230093,"about_ca_system_score_gemma":0.001030134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001445719,"about_ca_topic_score_gemma":0.00230871,"domain_scores_codex":[0.9998342,0.00003772663,0.00001246762,0.00002495338,0.00004165321,0.00004899194],"domain_scores_gemma":[0.9998323,0.00002514883,0.00002386891,0.00001130344,0.00002172222,0.00008572586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02481142,0.01612557,0.005307424,0.0008826426,0.0003029619,0.002765068,0.0003194279,0.004163926,0.718148,0.001910516,0.01898254,0.2062805],"study_design_scores_gemma":[0.05615214,0.3330053,0.04101853,0.0003039784,0.0007569576,0.0105689,0.0002251781,0.01178443,0.4582828,0.001346252,0.08642042,0.0001351298],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656106,0.01047287,0.003841007,0.002870642,0.000312865,0.001401363,0.00330687,0.0005234093,0.0116604],"genre_scores_gemma":[0.9723298,0.006377351,0.002959431,0.001980672,0.0002084047,0.0006421937,0.00556392,0.00007188521,0.009866314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002226289,"threshold_uncertainty_score":0.00744772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05350319283138538,"score_gpt":0.4208308633784346,"score_spread":0.3673276705470492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}