{"id":"W4409822152","doi":"10.1158/1538-7445.am2025-ct112","title":"Abstract CT112: Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of FXX489 ([<i>177</i>Lu]Lu-NNS309) in patients with pancreatic, lung, breast and colorectal cancers","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Jewish General Hospital; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Tolerability; Medicine; Dosimetry; Nuclear medicine; Breast cancer; Oncology; Internal medicine; Radiology; Adverse effect; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00123042,0.001948774,0.002181866,0.000420791,0.0006239747,0.001139906,0.001050736,0.001314691,0.005421464],"category_scores_gemma":[0.0009159,0.0006510809,0.001188029,0.0006204791,0.00114293,0.001101384,0.0004296152,0.003275374,0.001500833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001876195,"about_ca_system_score_gemma":0.002172097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001863476,"about_ca_topic_score_gemma":0.003603341,"domain_scores_codex":[0.9995017,0.000222904,0.00002805448,0.0001189858,0.00005609712,0.0000723108],"domain_scores_gemma":[0.9992118,0.00007821673,0.0001697044,0.00008692087,0.00006500394,0.0003883305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6617481,0.0672215,0.01325031,0.00143832,0.001483381,0.0005282634,0.0003872641,0.004539556,0.1730169,0.0003589152,0.007346475,0.06868099],"study_design_scores_gemma":[0.2919517,0.6644968,0.02017325,0.00005760362,0.0006424187,0.00103215,0.0001138868,0.001668721,0.01404736,0.0001853236,0.005564863,0.00006582675],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898117,0.001399011,0.001003565,0.0003051397,0.00006811847,0.002393955,0.002542094,0.0002159505,0.002260512],"genre_scores_gemma":[0.9835281,0.0008717219,0.002169594,0.0006591672,0.0001023396,0.003385059,0.005755563,0.00007389517,0.003454532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005421464,"threshold_uncertainty_score":0.01813656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08399891952655011,"score_gpt":0.4855390130873604,"score_spread":0.4015400935608102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}