{"id":"W4409822268","doi":"10.1158/1538-7445.am2025-ct088","title":"Abstract CT088: Clinical validation of a novel blood-based protein multi-analyte test for early detection of pancreatic ductal adenocarcinoma (PDAC) in a large, independent high-risk patient population","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"","keywords":"Pancreatic ductal adenocarcinoma; Medicine; Pancreatic cancer; Analyte; Population; Oncology; Internal medicine; Blood test; Cancer; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003248155,0.0006776797,0.0004838894,0.0005796902,0.0004488907,0.000938669,0.0007445403,0.0009397097,0.001266811],"category_scores_gemma":[0.006587824,0.0003035308,0.0003974639,0.0005410621,0.0005528956,0.0003949653,0.0005784075,0.000693235,0.000741953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006271743,"about_ca_system_score_gemma":0.0006220837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009018398,"about_ca_topic_score_gemma":0.0009631688,"domain_scores_codex":[0.9977736,0.0007386115,0.0001280185,0.000685383,0.0006011989,0.00007321829],"domain_scores_gemma":[0.9973322,0.0006580405,0.0004616827,0.0004943439,0.000727365,0.0003263826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01610106,0.002393627,0.8462871,0.000213812,0.0004869088,0.0005087294,0.0003391969,0.004125541,0.09675204,0.0003191375,0.002823538,0.02964939],"study_design_scores_gemma":[0.00189954,0.03378471,0.8210658,0.00007989203,0.0004914177,0.006493231,0.0003025437,0.05107734,0.07693224,0.0004891003,0.007262984,0.0001212347],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907349,0.0003189097,0.005602378,0.00009425264,0.00005907496,0.0003221616,0.001670882,0.0001637134,0.00103372],"genre_scores_gemma":[0.9928157,0.00004339905,0.004263298,0.0001103261,0.00002330946,0.0002182977,0.002037938,0.0000209239,0.0004668312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003248155,"threshold_uncertainty_score":0.01717812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1017602829843113,"score_gpt":0.4485681429446978,"score_spread":0.3468078599603864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}