{"id":"W4409822417","doi":"10.1158/1538-7445.am2025-ct011","title":"Abstract CT011: Penpulimab versus placebo in combination with chemotherapy as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma: A global, multicenter, randomized, double-blind, phase 3 trial (AK105-304)","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Nasopharyngeal carcinoma; Medicine; Placebo; Chemotherapy; Internal medicine; Oncology; Phases of clinical research; Double blind; First line; Radiation therapy; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002047389,0.002103889,0.002830431,0.0004951032,0.0004652836,0.001301182,0.001174146,0.001743458,0.01040996],"category_scores_gemma":[0.001270876,0.0006495676,0.001894397,0.0006157206,0.001304234,0.001153647,0.0004192814,0.003267313,0.00166745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006729301,"about_ca_system_score_gemma":0.001579038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000686455,"about_ca_topic_score_gemma":0.001609642,"domain_scores_codex":[0.9993491,0.0003925185,0.00003923619,0.0000999324,0.00004031374,0.0000790357],"domain_scores_gemma":[0.9991443,0.0001809051,0.0002510904,0.00005387552,0.00006053103,0.0003092945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.979682,0.006214096,0.0002737772,0.0005483091,0.0004271539,0.00003554295,0.00002611009,0.0001971505,0.003290051,0.00005860523,0.0008924486,0.008354834],"study_design_scores_gemma":[0.8920605,0.1057154,0.0008182451,0.0000304455,0.0002505625,0.0000407893,0.00001534749,0.0002120933,0.0004268909,0.00005250993,0.0003662397,0.0000109362],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766276,0.007081027,0.001020297,0.0009623531,0.0009955065,0.006648927,0.002233122,0.0004815149,0.003949601],"genre_scores_gemma":[0.9803779,0.003071228,0.001538568,0.001446432,0.0006531324,0.005402622,0.002251003,0.00004801128,0.005211158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01040996,"threshold_uncertainty_score":0.03482473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2077701317569146,"score_gpt":0.5059154631255456,"score_spread":0.298145331368631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}