{"id":"W4409822445","doi":"10.1158/1538-7445.am2025-ct016","title":"Abstract CT016: First-in-human (FIH) phase 1 trial of the oral first-in-class covalent Werner helicase (WRN) inhibitor RO7589831 in patients with microsatellite instable (MSI) and/or mismatch repair deficient (dMMR) advanced solid tumors","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Helicase; Werner syndrome; Class (philosophy); Genetics; Medicine; Biology; Philosophy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008943744,0.001812732,0.00145653,0.0004369875,0.0004864371,0.0008760451,0.0007773582,0.001200373,0.008348661],"category_scores_gemma":[0.0005995978,0.000458895,0.0008201099,0.0003424139,0.0008905886,0.0007479816,0.0003662058,0.003118649,0.001458448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001166664,"about_ca_system_score_gemma":0.001542075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001502615,"about_ca_topic_score_gemma":0.004553634,"domain_scores_codex":[0.9997233,0.0001053478,0.00001419784,0.00005128584,0.00003069382,0.00007516211],"domain_scores_gemma":[0.9995338,0.00006065334,0.00008865136,0.000035514,0.00002604437,0.0002552778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7283791,0.06229057,0.00788811,0.001057766,0.0008226006,0.000490343,0.0002364332,0.003381077,0.0798907,0.0004226211,0.01339172,0.1017489],"study_design_scores_gemma":[0.3876815,0.5829048,0.01560028,0.00005061384,0.0002534576,0.0004924047,0.00005473,0.001215575,0.007430089,0.000184911,0.004094033,0.00003766897],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873714,0.001484944,0.0004438434,0.0004526734,0.0001191145,0.002570161,0.003709248,0.0001735676,0.003675025],"genre_scores_gemma":[0.978237,0.001073069,0.001502833,0.0009694015,0.0002204667,0.002070805,0.007994327,0.00004133355,0.007890753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008348661,"threshold_uncertainty_score":0.02792907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03767165438988408,"score_gpt":0.3825345335230879,"score_spread":0.3448628791332038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}