{"id":"W4409839248","doi":"10.1016/j.jaip.2025.04.032","title":"Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data","year":2025,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto; Université Laval; University of Alberta; Vancouver General Hospital; Queen's University; Université de Sherbrooke; Vancouver Hospital and Health Sciences Centre","funders":"Daiichi Sankyo Europe; Department of Medicine, University of Toronto; Efficacy and Mechanism Evaluation Programme; Novo Nordisk; Sanofi Genzyme; Teijin Pharma; Shionogi; UCB Pharma; Meiji Seika Pharma; University of Toronto; Queen's University; Canadian Institutes of Health Research; Sanofi; Kuwait Foundation for the Advancement of Sciences; Michael Smith Health Research BC; Canadian Lung Association; AstraZeneca; Insmed; Genentech; United Therapeutics Corporation; Horizon Therapeutics; Celltrion; American Thoracic Society; Optimum Patient Care; Allergy Therapeutics; Canadian Thoracic Society; Novartis Pharmaceuticals UK Limited; National Institute for Health and Care Research; Glenmark Pharmaceuticals; CSL Behring; British Columbia Lung Association; Singapore General Hospital; Teva Pharmaceutical Industries; Bristol-Myers Squibb; European Respiratory Society; Government of Ontario; Regeneron Pharmaceuticals; Grifols; GlaxoSmithKline; Cerecor; Chiesi Farmaceutici; Covis Pharma; Danone; Gilead Sciences; Incyte; Medical Research Council; Eli Lilly and Company; Amgen; Pfizer","keywords":"Medicine; Asthma; Corticosteroid; Database; Pediatrics; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0415486,0.00148519,0.006014384,0.005005226,0.0003015317,0.002583573,0.001532142,0.001478487,0.001107434],"category_scores_gemma":[0.05069673,0.001085806,0.02077223,0.007085896,0.0005189558,0.001403954,0.002147842,0.001232457,0.0001857907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008347741,"about_ca_system_score_gemma":0.001128045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006563609,"about_ca_topic_score_gemma":0.005346207,"domain_scores_codex":[0.9419818,0.03815659,0.007550521,0.00690451,0.004086374,0.001320226],"domain_scores_gemma":[0.9225767,0.04168719,0.02398654,0.008563415,0.002375932,0.0008101963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007417302,0.00008296014,0.7423046,0.002705626,0.2373998,0.0001502345,0.0001220542,0.002066188,0.0002263677,0.0001367079,0.001005747,0.006382353],"study_design_scores_gemma":[0.001210554,0.001086986,0.8312585,0.0006330442,0.1576349,0.0004412639,0.0002187294,0.005102967,0.0002804289,0.0002782829,0.0017535,0.0001009474],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8994763,0.06377806,0.007688545,0.00067769,0.0002746036,0.0003850704,0.02601376,0.0001777198,0.001528263],"genre_scores_gemma":[0.9854542,0.0031624,0.001903489,0.0001903124,0.0001290448,0.0003258777,0.008623083,0.00003189887,0.0001796859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0415486,"threshold_uncertainty_score":0.2197326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.115982853111496,"score_gpt":0.473076375708202,"score_spread":0.357093522596706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}