{"id":"W4409846733","doi":"10.1101/2025.04.26.649666","title":"Antibiotic Resistance in <i>Staphylococcus aureus</i> : Effects of Quorum Sensing Inhibition and DNA Fragmentation","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hops Chemistry and Applications","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kwantlen Polytechnic University","funders":"Kwantlen Polytechnic University","keywords":"Staphylococcus aureus; Quorum sensing; Microbiology; Antibiotic resistance; Ciprofloxacin; Antibiotics; Antimicrobial; Ofloxacin; Efflux; Biofilm; Biology; Chemistry; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002120153,0.00028542,0.0002212054,0.0002207717,0.0001152631,0.000204883,0.000158536,0.0003074273,0.001431014],"category_scores_gemma":[0.0002447114,0.00009746051,0.0002560464,0.0001390541,0.0001472661,0.0001731372,0.0001330942,0.0003487765,0.0001739139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001543151,"about_ca_system_score_gemma":0.0001727316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006361624,"about_ca_topic_score_gemma":0.0007447149,"domain_scores_codex":[0.9997573,0.00007353981,0.0000270427,0.00004287674,0.00006034274,0.00003891312],"domain_scores_gemma":[0.9997405,0.00008510416,0.00007709644,0.00001607763,0.00004750571,0.00003365635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002318943,0.00008936256,0.0002963449,0.000134408,0.00001256227,0.00005895643,0.00002098559,0.00008232065,0.9966341,0.0000323144,0.00006498903,0.002341728],"study_design_scores_gemma":[0.00001402906,0.001650185,0.004213283,0.00002323195,0.00002112463,0.0001945165,0.00005113225,0.0006545116,0.9919709,0.00002673808,0.001172395,0.000007909852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923767,0.00399314,0.001309153,0.0001242231,0.00004966131,0.00005447699,0.0002638689,0.00004175661,0.001786942],"genre_scores_gemma":[0.9961254,0.001005623,0.001596765,0.00008966175,0.00001231767,0.00004036772,0.0002489908,0.000006144073,0.0008747117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431014,"threshold_uncertainty_score":0.004787207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02092402473020894,"score_gpt":0.3128703430934988,"score_spread":0.2919463183632898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}