{"id":"W4409852860","doi":"10.1101/2025.04.24.650479","title":"An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Division of Chemistry; Genentech; UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Genomics; Genome Canada; McGill University; North Carolina Biotechnology Center; Bayer; Bristol-Myers Squibb; Pfizer; National Science Foundation","keywords":"Chikungunya; Enantioselective synthesis; Helicase; Virology; Computer science; Chemistry; Physics; Biology; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002570422,0.0003384478,0.0001810395,0.0001131363,0.0001513382,0.0001983738,0.0002569393,0.0003124808,0.002150892],"category_scores_gemma":[0.0001648592,0.000128188,0.0001684266,0.0001057323,0.0002027117,0.0001407761,0.0001552057,0.000411387,0.0004497948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002414917,"about_ca_system_score_gemma":0.0001821044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005590173,"about_ca_topic_score_gemma":0.0007150808,"domain_scores_codex":[0.9998784,0.00002834039,0.000005679306,0.00002673506,0.00003000782,0.0000307735],"domain_scores_gemma":[0.9999377,0.00001442933,0.00001545233,0.00001048229,0.00001006653,0.00001192944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008346976,0.00002455565,0.00007911045,0.00003123204,0.000004618586,0.00004731362,0.00001322426,0.0001290639,0.9978036,0.0002428693,0.00007263516,0.001468203],"study_design_scores_gemma":[0.00001767983,0.0002359035,0.0003073624,0.000001916103,0.000004671638,0.00009442466,0.000007171494,0.000515316,0.9974051,0.00002507357,0.001381469,0.000003904488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796643,0.001296786,0.009021401,0.000202654,0.00005455638,0.00008484854,0.0004482535,0.0001279719,0.009099239],"genre_scores_gemma":[0.9854693,0.0009285093,0.007852823,0.0001506413,0.00002237427,0.0000480754,0.0004301406,0.00002686846,0.005071377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002150892,"threshold_uncertainty_score":0.007195473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009581848874128955,"score_gpt":0.2567148027574703,"score_spread":0.2471329538833413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}