{"id":"W4409867894","doi":"10.21203/rs.3.rs-5982826/v1","title":"PGC-1 alpha overexpression in the skeletal muscle results in a metabolically active microbiome which is independent of redox signaling","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"","keywords":"Microbiome; Skeletal muscle; Redox; Alpha (finance); Chemistry; Cell biology; Biochemistry; Signal transduction; Biology; Bioinformatics; Endocrinology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002861379,0.0005100484,0.0005224075,0.0004025255,0.0002539026,0.000609318,0.000244473,0.0006939513,0.004452525],"category_scores_gemma":[0.0002287528,0.0003928504,0.0004665818,0.0003331898,0.0006552278,0.0004236654,0.0005002083,0.001561699,0.001446909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002991747,"about_ca_system_score_gemma":0.0003256674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005864481,"about_ca_topic_score_gemma":0.0006958029,"domain_scores_codex":[0.9997439,0.00002664528,0.00001641587,0.00008748873,0.00006996989,0.00005555943],"domain_scores_gemma":[0.9996697,0.00006125314,0.00009100167,0.00005016291,0.00002463994,0.0001032629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006085945,0.00003152564,0.000182637,0.00005871001,0.00001051636,0.00008780764,0.00001647462,0.00005683595,0.9972702,0.0003071216,0.0002465552,0.001123098],"study_design_scores_gemma":[0.0001513619,0.0003710839,0.01282602,0.00003062762,0.00004361407,0.0004734244,0.0001334688,0.001044745,0.9773046,0.000607205,0.0070019,0.00001201922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659729,0.002899762,0.01320763,0.002424868,0.001516975,0.00006236033,0.005048457,0.0007677214,0.008099237],"genre_scores_gemma":[0.9465473,0.002339032,0.007265417,0.0006489391,0.0001575527,0.0001131562,0.003959309,0.0004664599,0.03850286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004452525,"threshold_uncertainty_score":0.0148952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0477543717911135,"score_gpt":0.3976257714999458,"score_spread":0.3498713997088323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}