{"id":"W4409870398","doi":"10.1128/iai.00081-25","title":"Evidence for a model of conformational change by the <i>Plasmodium falciparum</i> circumsporozoite protein during sporozoite development in the mosquito host through the use of camelid single-domain antibodies","year":2025,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Universiteit Antwerpen; Fonds Wetenschappelijk Onderzoek; Agence Nationale de la Recherche","keywords":"Circumsporozoite protein; Epitope; Biology; Antibody; Midgut; Molecular biology; Algorithm; Immunology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012705,0.0001666638,0.0002392892,0.00009493226,0.0005818574,0.00003440369,0.0002519849,0.0001361878,0.000009121465],"category_scores_gemma":[0.0002498224,0.00009813485,0.00007076746,0.0002388393,0.000368274,0.0004090873,0.0001401535,0.0002945344,0.000002459242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005932479,"about_ca_system_score_gemma":0.0001135858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001649526,"about_ca_topic_score_gemma":0.0003292112,"domain_scores_codex":[0.9985802,0.0005011337,0.0004906232,0.0001333237,0.00006678244,0.000227906],"domain_scores_gemma":[0.9986859,0.0005414531,0.0002736213,0.0003351535,0.0001588563,0.000005042901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006730616,0.0001759354,0.001059791,0.0001763294,0.0001096513,1.396455e-7,0.01566186,0.00006327431,0.97677,0.004064855,0.0001868431,0.001058255],"study_design_scores_gemma":[0.001439259,0.0001630029,0.01780074,0.0005829384,0.00004314602,0.00002894543,0.002324974,0.0004000647,0.9692697,0.0006905101,0.007076193,0.0001805304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929441,0.001527753,0.003189521,0.0006367985,0.0001569168,0.001422125,0.00005246923,0.00001632972,0.00005395548],"genre_scores_gemma":[0.9985933,0.0002242846,0.0001427466,0.0004135428,0.000004355457,0.0003403075,0.00003968368,0.000007286003,0.0002345505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01674094,"threshold_uncertainty_score":0.4475235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1169065379677896,"score_gpt":0.2895625520563893,"score_spread":0.1726560140885997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}