{"id":"W4409870398","doi":"10.1128/iai.00081-25","title":"Evidence for a model of conformational change by the <i>Plasmodium falciparum</i> circumsporozoite protein during sporozoite development in the mosquito host through the use of camelid single-domain antibodies","year":2025,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Universiteit Antwerpen; Fonds Wetenschappelijk Onderzoek; Agence Nationale de la Recherche","keywords":"Circumsporozoite protein; Epitope; Biology; Antibody; Midgut; Molecular biology; Algorithm; Immunology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127173,0.0002446612,0.0001149863,0.0001232316,0.0001346905,0.0001975441,0.0003670776,0.0002597413,0.00256711],"category_scores_gemma":[0.0001446013,0.0001266118,0.000330956,0.00006703578,0.0001917245,0.0003255358,0.0001309467,0.0004181724,0.0005293556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271003,"about_ca_system_score_gemma":0.0000787988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005813675,"about_ca_topic_score_gemma":0.0003050995,"domain_scores_codex":[0.9999422,0.00001025002,0.000003642639,0.00001828607,0.00001024635,0.00001528272],"domain_scores_gemma":[0.9999164,0.00002278413,0.00002268239,0.00001065518,0.00001339382,0.0000141099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001950023,0.00004965378,0.0012266,0.00007735263,0.00001424593,0.0002510113,0.00004312682,0.0002710643,0.9958255,0.0008341256,0.0002013263,0.0010109],"study_design_scores_gemma":[0.00009890555,0.0009713023,0.0321136,0.00003357235,0.00007373506,0.001734938,0.0001563049,0.02108677,0.9333298,0.001200291,0.009173936,0.00002681826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890387,0.00071391,0.005708938,0.0002651802,0.0000530916,0.00002263339,0.0002230164,0.00009951286,0.003875095],"genre_scores_gemma":[0.9961566,0.0003264745,0.001872862,0.0001627345,0.00001037513,0.00001405451,0.0003804835,0.00001545542,0.001061081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00256711,"threshold_uncertainty_score":0.008587837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1169065379677896,"score_gpt":0.2895625520563893,"score_spread":0.1726560140885997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}