{"id":"W4409872939","doi":"10.1002/chem.202500382","title":"Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP‐Lyase Function","year":2025,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Agencia Estatal de Investigación; Innovative Medicines Initiative; Novo Nordisk Fonden; Vetenskapsrådet; Kungliga Tekniska Högskolan; Barncancerfonden; Stockholms Universitet; Cancerfonden; Karolinska Institutet; European Commission; Diamond Light Source; Novo Nordisk; European Federation of Pharmaceutical Industries and Associations; McGill University; Åke Wiberg Stiftelse","keywords":"DNA glycosylase; Enzyme; Chemistry; Active site; Biochemistry; DNA; Combinatorial chemistry; Stereochemistry; DNA repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298288,0.0003149378,0.0001605532,0.00008771018,0.00006212243,0.0002187671,0.0002063666,0.0001958339,0.0009734376],"category_scores_gemma":[0.0001214778,0.00009215079,0.0001476936,0.000076842,0.0001421,0.0001835982,0.0002002778,0.0004485462,0.0002222805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002229159,"about_ca_system_score_gemma":0.0001493019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002101566,"about_ca_topic_score_gemma":0.000357346,"domain_scores_codex":[0.9999313,0.00001058854,0.000004807503,0.00001789206,0.00001751063,0.00001789682],"domain_scores_gemma":[0.9999543,0.000008023933,0.00001513516,0.000006026568,0.000005920395,0.0000105035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001441641,0.00004850127,0.000130207,0.00007949184,0.000009359414,0.00005253609,0.00001706993,0.00056139,0.9941515,0.0004184548,0.00009271442,0.004294629],"study_design_scores_gemma":[0.0000302016,0.0008056603,0.0004705667,0.000006268773,0.000008767208,0.00007886283,0.00001119189,0.0009262124,0.9942385,0.00007863287,0.003339315,0.000005876866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848095,0.002133107,0.008519758,0.0001187499,0.00004740888,0.00009392582,0.000386962,0.0001735728,0.003717019],"genre_scores_gemma":[0.9937256,0.0008292074,0.003907183,0.00003911349,0.000006619388,0.00003382767,0.0001890989,0.00001098891,0.00125836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009734376,"threshold_uncertainty_score":0.00325644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004216246949572755,"score_gpt":0.1973700767930677,"score_spread":0.193153829843495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}