{"id":"W4409874925","doi":"10.1371/journal.pmed.1004589","title":"SPIRIT 2025 statement: Updated guideline for protocols of randomised trials","year":2025,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Meta-analysis and systematic reviews","field":"Decision Sciences","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; University of Alberta; Robarts Clinical Trials; University of Toronto; SickKids Foundation; St. Joseph’s Healthcare Hamilton; Hospital for Sick Children; Ottawa Hospital; McMaster University; Women's College Hospital","funders":"University of North Carolina at Chapel Hill; Jawaharlal Institute Of Postgraduate Medical Education and Research; Syddansk Universitet; Centers for Disease Control and Prevention; University of Aberdeen; University of Glasgow; University of Oxford; University of Toronto; University College London; University of Exeter; National Institute for Health and Care Research; South African Medical Research Council; University of Alberta; Medical Research Council; London School of Hygiene and Tropical Medicine; McMaster University; Ottawa Hospital Research Institute; Hospital for Sick Children; Northwestern University; University of Warwick; University of Ottawa; Bond University; University of Miami","keywords":"Checklist; Protocol (science); Consolidated Standards of Reporting Trials; Delphi method; Guideline; Medicine; MEDLINE; Delphi; Clinical trial; Psychological intervention; Medical education; Family medicine; Alternative medicine; Computer science; Psychology; Nursing; Pathology; Political science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","insufficient_payload"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3156661,0.0002737375,0.00865305,0.0006565005,0.00007222787,0.00009110422,0.001337838,0.0000758172,0.03041774],"category_scores_gemma":[0.3432607,0.000108573,0.001400136,0.001628237,0.00009611055,0.00008845128,0.00007532025,0.00007888686,0.0001828814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002443062,"about_ca_system_score_gemma":0.0001794486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001007171,"about_ca_topic_score_gemma":0.000006317997,"domain_scores_codex":[0.9473488,0.009770561,0.03718225,0.0008704034,0.00454779,0.0002801393],"domain_scores_gemma":[0.9686149,0.01455207,0.01036804,0.002747806,0.003593205,0.0001239688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006883689,0.0001077816,0.0002976226,0.0002862803,0.0008600031,7.855363e-7,0.0001107074,0.00001269077,0.002310661,0.001489176,0.9757481,0.01808788],"study_design_scores_gemma":[0.01937591,0.000160257,0.00004458806,0.0005112767,0.001213631,2.385765e-7,0.0002591845,0.005319875,0.001960582,0.008350628,0.9627156,0.00008823702],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.002650402,0.003769786,0.5950099,0.09752564,0.000967177,0.257469,0.0002474696,0.00003350183,0.04232719],"genre_scores_gemma":[0.06255111,0.0004259173,0.1835372,0.02426049,0.002954936,0.1902197,0.001266916,0.0001451906,0.5346385],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.4923114,"threshold_uncertainty_score":0.9704686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8747243100184403,"score_gpt":0.6535485697604634,"score_spread":0.2211757402579769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}