{"id":"W4409877426","doi":"10.33540/2859","title":"Unraveling HIV Reservoir Persistence and Dynamics in Peripheral Blood and the Central Nervous System during Antiretroviral Therapy","year":2025,"lang":"en","type":"dissertation","venue":"","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Antiretroviral therapy; Persistence (discontinuity); Human immunodeficiency virus (HIV); Central nervous system; Peripheral blood; Medicine; Dynamics (music); Peripheral; Immunology; Neuroscience; Virology; Biology; Viral load; Psychology; Internal medicine; Geology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006408344,0.0002234236,0.0005466017,0.0006413666,0.0003400722,0.0015093,0.0003447281,0.000468445,0.0008374873],"category_scores_gemma":[0.0008950543,0.0002367368,0.0002252176,0.000374651,0.000268617,0.0009749686,0.0004112869,0.0007757823,0.0002638466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004209689,"about_ca_system_score_gemma":0.0005288316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001713336,"about_ca_topic_score_gemma":0.001885264,"domain_scores_codex":[0.9997222,0.00005769098,0.0000182303,0.00006164902,0.00008701786,0.00005324229],"domain_scores_gemma":[0.999675,0.00009253949,0.00008895448,0.00001786688,0.00009966933,0.00002599807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007277111,0.000209804,0.1014064,0.0008491888,0.000138183,0.0008341682,0.001659062,0.002636005,0.7490615,0.001677339,0.001505875,0.1392947],"study_design_scores_gemma":[0.00004769474,0.002750734,0.4506218,0.001080376,0.0005651718,0.004598774,0.003412423,0.04344325,0.436334,0.005757843,0.05117241,0.0002154406],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553921,0.02752046,0.01235279,0.0006694407,0.0001017421,0.00009851254,0.0007034376,0.0001060864,0.003055431],"genre_scores_gemma":[0.9723766,0.01392241,0.01025648,0.0002702378,0.00009482891,0.0001227175,0.0006461258,0.00004141358,0.002269135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713336,"threshold_uncertainty_score":0.003406703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009190925433273985,"score_gpt":0.2300270347680938,"score_spread":0.2208361093348198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}