{"id":"W4409879700","doi":"10.1016/j.clbc.2025.04.017","title":"Safety and Effectiveness of Adriamycin and Cyclophosphamide Followed by Dose Dense (Every 2 Weeks) Paclitaxel Given With Trastuzumab as Neoadjuvant Treatment in HER2-Positive Early-Stage Breast Cancer","year":2025,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St Mary's Hospital Centre; McGill University; Princess Margaret Cancer Centre","funders":"University Health Network","keywords":"Medicine; Trastuzumab; Breast cancer; Regimen; Oncology; Anthracycline; Internal medicine; Discontinuation; Neoadjuvant therapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00152468,0.0005604851,0.001395777,0.0003560922,0.0003423853,0.0005391137,0.0005455054,0.0007178597,0.001314668],"category_scores_gemma":[0.001966639,0.0002517128,0.0005752742,0.0005027752,0.0007828202,0.0005492263,0.0001593184,0.001301904,0.0002186251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007579882,"about_ca_system_score_gemma":0.0009464641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242956,"about_ca_topic_score_gemma":0.00248448,"domain_scores_codex":[0.9990727,0.0006827131,0.00004005449,0.00007026645,0.00005024193,0.00008405976],"domain_scores_gemma":[0.9986244,0.0005996167,0.0002069653,0.0001810256,0.000059117,0.000328741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8665636,0.01736592,0.01012616,0.0002857365,0.0004748437,0.000191004,0.00013388,0.00161385,0.0217683,0.0001874176,0.0004516682,0.08083754],"study_design_scores_gemma":[0.09280402,0.7991384,0.08456167,0.00009432776,0.0008814382,0.0005503069,0.0001496605,0.00157733,0.01666423,0.0002722547,0.003251629,0.00005474287],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964634,0.002257658,0.0000902103,0.00009775999,0.00004211825,0.00009398609,0.0001256753,0.00001036738,0.0008189056],"genre_scores_gemma":[0.9980571,0.0008958511,0.0001097373,0.00007556236,0.00007685454,0.00006804787,0.000182269,0.000004868677,0.0005297009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00152468,"threshold_uncertainty_score":0.008063436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005940179759944021,"score_gpt":0.2996759952733951,"score_spread":0.2937358155134511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}