{"id":"W4409879700","doi":"10.1016/j.clbc.2025.04.017","title":"Safety and Effectiveness of Adriamycin and Cyclophosphamide Followed by Dose Dense (Every 2 Weeks) Paclitaxel Given With Trastuzumab as Neoadjuvant Treatment in HER2-Positive Early-Stage Breast Cancer","year":2025,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St Mary's Hospital Centre; McGill University; Princess Margaret Cancer Centre","funders":"University Health Network","keywords":"Medicine; Trastuzumab; Breast cancer; Regimen; Oncology; Anthracycline; Internal medicine; Discontinuation; Neoadjuvant therapy; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000313406,0.0004792711,0.0009187409,0.0000638842,0.0001115129,0.00002379097,0.000128442,0.0002687199,0.0000279153],"category_scores_gemma":[0.00003533532,0.0003724767,0.0001566022,0.0002255343,0.000594051,0.00001945343,0.0001685471,0.0001790581,0.000001192756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003190723,"about_ca_system_score_gemma":0.0004701983,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01378519,"about_ca_topic_score_gemma":0.003275607,"domain_scores_codex":[0.9974409,0.0003801517,0.0005885763,0.0009889881,0.0001688451,0.0004325284],"domain_scores_gemma":[0.9987388,0.0003320893,0.0002190809,0.0003629256,0.0001619598,0.0001851031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02514126,0.0008170952,0.9335729,0.0001376077,0.001439819,0.00004539892,0.0001735754,0.00004783988,0.003663541,0.00003158986,0.000163447,0.03476596],"study_design_scores_gemma":[0.01166688,0.0008567002,0.9810554,0.0008021006,0.0003368489,0.00004381452,0.00017999,0.000007422732,0.003894302,0.0000279326,0.0007699832,0.0003586744],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857512,0.008526376,0.00005060458,0.001197532,0.000197388,0.0008356969,0.003262188,0.00001546902,0.0001635572],"genre_scores_gemma":[0.9883724,0.0103486,0.00004509211,0.0002345023,0.00009122382,0.0003921404,0.00008260789,0.00004050305,0.0003928868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04748249,"threshold_uncertainty_score":0.9998727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005940179759944021,"score_gpt":0.2996759952733951,"score_spread":0.2937358155134511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}