{"id":"W4409889295","doi":"10.1021/acs.jmedchem.5c00220","title":"Broad Target Screening Reveals Abundance of FKBP12-Based Molecular Glues in Focused Libraries","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"Structural Genomics Consortium; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"FKBP; Drug discovery; Chemistry; Computational biology; Drug repositioning; Drug; Biochemistry; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000538299,0.0001745365,0.0003734782,0.00007406926,0.00002674181,0.0000139677,0.0004420329,0.000181708,0.00004052378],"category_scores_gemma":[0.001052995,0.0001638438,0.0001855952,0.0002207567,0.0002000181,0.000008385587,0.00006940805,0.0002773441,2.177529e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000252598,"about_ca_system_score_gemma":0.0005342003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005251496,"about_ca_topic_score_gemma":4.206946e-7,"domain_scores_codex":[0.9984831,0.0000663799,0.0006776631,0.0002028978,0.000356503,0.0002134395],"domain_scores_gemma":[0.9988409,0.0000655995,0.0004589623,0.0002974466,0.0002151151,0.0001219436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006718252,0.0001117376,0.0189597,0.0003079864,0.0000887987,0.0001182044,0.0000249656,0.0009452745,0.9760877,0.00001547895,0.001949978,0.000718344],"study_design_scores_gemma":[0.001840989,0.0001422081,0.001458049,0.001040274,0.00005424826,0.00002072996,0.00009683283,0.00008553552,0.9930989,0.0006167012,0.001416941,0.000128584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717408,0.01275825,0.01378305,0.0005795257,0.0001100509,0.00006717439,0.00001089696,0.000005456692,0.0009448277],"genre_scores_gemma":[0.9906429,0.0000389713,0.008556519,0.0004257881,0.0001780097,0.000003513116,0.00001742756,0.00001616263,0.0001207111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01890213,"threshold_uncertainty_score":0.6681356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007855922478821418,"score_gpt":0.2601915578116911,"score_spread":0.2523356353328696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}