{"id":"W4409890084","doi":"10.26434/chemrxiv-2025-ppm63","title":"Advanced Synthetic Strategies toward Ginkgolide Diterpenoids: Total Synthesis of (±)-Ginkgolide C and Formal Syntheses of (±)-Ginkgolides A and B","year":2025,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Ginkgo biloba and Cashew Applications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of North Carolina at Chapel Hill; Government of Ontario","keywords":"Ginkgolides; Stereochemistry; Formal synthesis; Chemistry; Total synthesis; Combinatorial chemistry; Pharmacology; Biology; Ginkgo biloba","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002965596,0.0007197881,0.0003539906,0.0005484499,0.0002720091,0.0003935422,0.0003709016,0.0002947221,0.002352313],"category_scores_gemma":[0.0002078692,0.0001783106,0.0003863278,0.0004865516,0.0003366105,0.000537659,0.0006096137,0.000862678,0.001822603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004033489,"about_ca_system_score_gemma":0.0007801861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005025647,"about_ca_topic_score_gemma":0.0009799382,"domain_scores_codex":[0.9998802,0.0000152085,0.00001350228,0.0000261638,0.00002493267,0.00003999774],"domain_scores_gemma":[0.9999218,0.000007330972,0.00001562396,0.00001669482,0.00001364893,0.00002484271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001495405,0.0001379933,0.0001648693,0.0005397137,0.00004143812,0.0004337434,0.0002155856,0.001522649,0.9594732,0.007691524,0.0006101356,0.02901962],"study_design_scores_gemma":[0.00008843826,0.0006593484,0.0006058351,0.0000536898,0.00005170048,0.0007045761,0.00007468878,0.0009687058,0.943307,0.002188316,0.05124804,0.00004965992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7618012,0.01626422,0.1671448,0.001055174,0.0005258914,0.001258844,0.003401401,0.001038847,0.0475096],"genre_scores_gemma":[0.8898796,0.01386045,0.0849091,0.0002690652,0.00008326267,0.0004117112,0.001594331,0.0001836038,0.0088088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002352313,"threshold_uncertainty_score":0.007869303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01724939601320279,"score_gpt":0.2790390541998353,"score_spread":0.2617896581866325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}