{"id":"W4409898948","doi":"10.1038/s41598-025-99827-7","title":"Complete omission of exon 21 from Slc12a2 transcripts in mice results in hearing loss","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute for Physiological Sciences; RIKEN; Uehara Memorial Foundation; Amgen Foundation","keywords":"Hearing loss; Exon; Biology; Genetics; Audiology; Computational biology; Medicine; Bioinformatics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004485964,0.0008893437,0.0005128576,0.0009798408,0.0005134429,0.0006012308,0.0005577844,0.001269269,0.005590635],"category_scores_gemma":[0.00032988,0.0006651617,0.0008661588,0.0004376891,0.0008217503,0.0003035358,0.0004791862,0.001484063,0.002097056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004124687,"about_ca_system_score_gemma":0.0004348634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008535242,"about_ca_topic_score_gemma":0.001769901,"domain_scores_codex":[0.9990655,0.0001047768,0.0001293656,0.0003306978,0.0002330587,0.0001366432],"domain_scores_gemma":[0.9993511,0.0001047431,0.000253871,0.00007291395,0.00004226086,0.0001751211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00036224,0.00007505448,0.0005110762,0.0001236271,0.00003508937,0.0005202693,0.00006459053,0.0001446839,0.9946709,0.0004598787,0.0003702649,0.002662201],"study_design_scores_gemma":[0.0002255355,0.0006660337,0.01646959,0.0001118874,0.0001826228,0.004295817,0.000156388,0.002312418,0.9428747,0.0006015272,0.03205698,0.00004640895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9489729,0.002269011,0.02603812,0.0007930578,0.0004977062,0.0002341899,0.01374322,0.001974328,0.0054775],"genre_scores_gemma":[0.9480592,0.001776231,0.01563495,0.0006977987,0.00008248521,0.0007806018,0.01322229,0.001414986,0.01833138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005590635,"threshold_uncertainty_score":0.01870257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06249243810197223,"score_gpt":0.2996261767448436,"score_spread":0.2371337386428714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}