{"id":"W4409901764","doi":"10.1242/dmm.052138","title":"Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations","year":2025,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Institute of Genetics; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta; Deutsche Forschungsgemeinschaft; Ministry of Advanced Education, Government of Alberta; Agence Nationale de la Recherche; Kidney Foundation of Canada","keywords":"Distal renal tubular acidosis; Urinary system; Paracellular transport; Internal medicine; Endocrinology; Biology; Phenotype; Metabolic acidosis; Sodium; Wasting; Homeostasis; Acidosis; Mutant; Chemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008758802,0.000147841,0.000107628,0.00009664503,0.0001849142,0.00002942139,0.00005270224,0.0000726791,0.000004912594],"category_scores_gemma":[0.00001107554,0.0001436543,0.00004379642,0.0002029556,0.00003190752,0.00001744554,0.00003119589,0.00006551848,3.593015e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002043065,"about_ca_system_score_gemma":0.00009032592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001450889,"about_ca_topic_score_gemma":0.00003364939,"domain_scores_codex":[0.9991384,0.00003218226,0.0001682442,0.0003575,0.0001160766,0.0001876137],"domain_scores_gemma":[0.9996746,0.000006970259,0.00004753069,0.0001232141,0.00006457338,0.00008313272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002493538,0.000384385,0.002837575,0.0002465554,0.0001501373,0.00006609969,0.0003873931,0.02936511,0.9550671,0.007176377,0.00003474197,0.001791006],"study_design_scores_gemma":[0.007670132,0.001118724,0.03726453,0.0008439298,0.0009342536,0.00004108588,0.002642743,0.4170253,0.4595645,0.07106904,0.0002555263,0.001570272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7321016,0.0003226741,0.2670697,0.000104134,0.00005863895,0.0001902887,0.00002268524,0.00001868507,0.0001116399],"genre_scores_gemma":[0.9981026,0.00002294684,0.0007727632,0.00006906533,0.00004097482,0.00007305154,0.0005880801,0.00001714136,0.0003133783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4955026,"threshold_uncertainty_score":0.5858051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008506389004778606,"score_gpt":0.2198836044268077,"score_spread":0.2113772154220291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}