{"id":"W4409901764","doi":"10.1242/dmm.052138","title":"Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations","year":2025,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Institute of Genetics; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta; Deutsche Forschungsgemeinschaft; Ministry of Advanced Education, Government of Alberta; Agence Nationale de la Recherche; Kidney Foundation of Canada","keywords":"Distal renal tubular acidosis; Urinary system; Paracellular transport; Internal medicine; Endocrinology; Biology; Phenotype; Metabolic acidosis; Sodium; Wasting; Homeostasis; Acidosis; Mutant; Chemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003779288,0.001030181,0.0005481479,0.001460928,0.0004101064,0.0006213851,0.0005757174,0.001081012,0.002625753],"category_scores_gemma":[0.0002833653,0.0005833994,0.0006888073,0.0004699221,0.0007015256,0.0004283311,0.0006666559,0.001114665,0.0006717623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003455993,"about_ca_system_score_gemma":0.0003449209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007735224,"about_ca_topic_score_gemma":0.001276476,"domain_scores_codex":[0.9993501,0.0001295442,0.0001219718,0.0001513443,0.0001607296,0.00008627168],"domain_scores_gemma":[0.9994728,0.00006701374,0.0002406618,0.00003503814,0.00002711204,0.0001573629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003472234,0.0001105668,0.0004873555,0.0000638548,0.00002805374,0.000685648,0.00005763115,0.0002009722,0.9960811,0.0004476975,0.0001001131,0.001389902],"study_design_scores_gemma":[0.0005383668,0.001824235,0.03078339,0.0001338946,0.0002726068,0.01236029,0.0002611765,0.004695641,0.9400732,0.00076136,0.008223556,0.00007225174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873254,0.0009204652,0.007362478,0.0002954867,0.00006509859,0.00009119535,0.001894698,0.0004980519,0.00154705],"genre_scores_gemma":[0.9837207,0.001449277,0.007186864,0.0001735369,0.00003018195,0.0001578394,0.001568159,0.0002083136,0.005505202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002625753,"threshold_uncertainty_score":0.008784056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008506389004778606,"score_gpt":0.2198836044268077,"score_spread":0.2113772154220291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}