{"id":"W4409903758","doi":"10.1038/s41598-025-99979-6","title":"BMP-2 mRNA-transfected BMSCs promote superior calvarial bone regeneration","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Bone Tissue Engineering Materials","field":"Engineering","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Transfection; Regeneration (biology); Cell biology; Bone morphogenetic protein 2; Messenger RNA; Calvaria; Chemistry; Biology; In vitro; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002039626,0.0004613861,0.0003040916,0.0004206797,0.0001587595,0.0003419591,0.0001507355,0.0003523019,0.00173713],"category_scores_gemma":[0.0001350859,0.0001737332,0.0002386793,0.0001866186,0.0002561322,0.0001932436,0.0002087079,0.0005310514,0.0004840765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307556,"about_ca_system_score_gemma":0.00040307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108047,"about_ca_topic_score_gemma":0.002347554,"domain_scores_codex":[0.9998224,0.00001824538,0.00001824733,0.00002212075,0.00008774152,0.00003130559],"domain_scores_gemma":[0.9999051,0.00002172289,0.00001759212,0.000009911149,0.00001846978,0.00002709564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003603665,0.00003626184,0.00007071748,0.00002936503,0.000002724732,0.00002509005,0.00001028978,0.00004202866,0.9986032,0.00006869336,0.00002881181,0.00104677],"study_design_scores_gemma":[0.00002109549,0.0001574308,0.001317684,0.000005110272,0.00001748374,0.00008097308,0.00002221715,0.0007111412,0.9952768,0.00002824698,0.002359167,0.000002663338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989355,0.002112622,0.004836242,0.0001285226,0.00007083653,0.0000786832,0.0002676797,0.0001591022,0.002991296],"genre_scores_gemma":[0.9822409,0.002382181,0.008421756,0.0001075009,0.00003937633,0.00008681761,0.0005323295,0.00005687083,0.006132337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173713,"threshold_uncertainty_score":0.005811214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006302408337904766,"score_gpt":0.2090642052299912,"score_spread":0.2027617968920864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}