{"id":"W4409907451","doi":"10.1016/j.toxlet.2025.04.013","title":"The induction of quinone oxidoreductases NQO1 and NQO2 by clozapine: Potential implications for clozapine-induced agranulocytosis","year":2025,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Clozapine; Pharmacology; Medicine; Chemistry; Schizophrenia (object-oriented programming); Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288363,0.0004107881,0.0003181342,0.0003210641,0.0001817833,0.0003203783,0.0002103669,0.0005080609,0.00110914],"category_scores_gemma":[0.0004006271,0.0001216916,0.0003661704,0.0001815254,0.0003211125,0.0002215135,0.0001988594,0.0003761848,0.0001774723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004443954,"about_ca_system_score_gemma":0.0002212832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001613358,"about_ca_topic_score_gemma":0.002009526,"domain_scores_codex":[0.999803,0.00006968794,0.00001778052,0.00002785566,0.00003650581,0.00004522014],"domain_scores_gemma":[0.9996723,0.00005405034,0.0001370224,0.00003172057,0.00005852328,0.00004635638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005558114,0.00007774771,0.002616277,0.0002970528,0.00004441352,0.0009852087,0.00006655419,0.0001182904,0.9902012,0.0003362884,0.0001996952,0.004501495],"study_design_scores_gemma":[0.0001268413,0.001741268,0.10972,0.00009462578,0.0002068592,0.003590076,0.0003670407,0.002007495,0.8655275,0.0013259,0.01524513,0.00004712096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9399496,0.04468575,0.008108653,0.001758255,0.0001778793,0.0001387279,0.0006462079,0.0002092964,0.004325636],"genre_scores_gemma":[0.9902464,0.006627859,0.001070979,0.0002359071,0.00005244448,0.00004304739,0.0002061553,0.000008226259,0.001509022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613358,"threshold_uncertainty_score":0.003710508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006743463011111516,"score_gpt":0.2522018285222672,"score_spread":0.2454583655111557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}