{"id":"W4409909460","doi":"10.1016/j.jcyt.2025.03.418","title":"DEVELOPMENT OF ROBUST T CELL MANUFACTURING PROTOCOLS IN BIOREACTORS USING CGMP-COMPLIANT ANCILLARY REAGENTS","year":2025,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stemcell Technologies","funders":"","keywords":"Bioreactor; Biochemical engineering; Computer science; Chemistry; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005254453,0.001261004,0.0006222551,0.0009230249,0.0007957963,0.001477064,0.001716137,0.001227339,0.003030868],"category_scores_gemma":[0.003947429,0.0006978911,0.0007841618,0.0005766518,0.0007093127,0.000779072,0.001074811,0.00225466,0.002883012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007738284,"about_ca_system_score_gemma":0.002620253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00103215,"about_ca_topic_score_gemma":0.002018776,"domain_scores_codex":[0.9966313,0.000789627,0.0004811809,0.0006223422,0.001285145,0.0001903473],"domain_scores_gemma":[0.9972538,0.0006502414,0.0005502931,0.0005904282,0.0007664582,0.0001888085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007577229,0.0001120187,0.0002244725,0.0001936656,0.00001257163,0.00008134422,0.00009648955,0.0009879757,0.9831246,0.001381525,0.0007037229,0.01300589],"study_design_scores_gemma":[0.00002369981,0.0002467846,0.0003198946,0.00003992919,0.00001556273,0.0001042727,0.00002130085,0.002320721,0.9854714,0.0003786368,0.01104016,0.00001780953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1010912,0.001380855,0.8779563,0.0004923734,0.0004600213,0.005142394,0.001615044,0.00270127,0.009160577],"genre_scores_gemma":[0.1619648,0.001455119,0.8207945,0.0004087783,0.0001051453,0.004164752,0.003400113,0.0005192832,0.007187397],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.005254453,"threshold_uncertainty_score":0.02778852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09941409715983572,"score_gpt":0.371884300204655,"score_spread":0.2724702030448193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}