{"id":"W4409912100","doi":"10.1016/j.xhgg.2025.100445","title":"Pathogenic germline variants in small cell lung cancer: A systematic review and meta-analysis","year":2025,"lang":"en","type":"review","venue":"Human Genetics and Genomics Advances","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre; Canada Research Chairs; Ontario Institute for Cancer Research; St. Michael's Hospital; Western University","funders":"National Cancer Institute; National Institutes of Health; Terry Fox Research Institute; Memorial Sloan-Kettering Cancer Center; University of Toronto; Canada Foundation for Innovation; Princess Margaret Cancer Foundation; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Meta-analysis; Germline; Lung cancer; Biology; Cancer; Genetics; Medicine; Oncology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01219014,0.002894442,0.01668251,0.006951421,0.0006405041,0.003104598,0.002025839,0.002033285,0.003386782],"category_scores_gemma":[0.02822501,0.001565117,0.03883703,0.008810297,0.0005721268,0.001610419,0.001474125,0.001665762,0.0003314837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002531971,"about_ca_system_score_gemma":0.00364492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008887907,"about_ca_topic_score_gemma":0.01996737,"domain_scores_codex":[0.9918791,0.004027033,0.00211441,0.0008733943,0.000775937,0.0003302283],"domain_scores_gemma":[0.9851795,0.01128885,0.001759015,0.0004436234,0.00114317,0.0001856607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001161247,0.00001815031,0.004597157,0.3558555,0.6256177,0.0001602337,0.00007712339,0.0007425643,0.0002197508,0.0001587666,0.000728704,0.01066304],"study_design_scores_gemma":[0.0002701916,0.0001244818,0.003372104,0.0231877,0.9710726,0.0001059042,0.00003884106,0.0001730401,0.00007997741,0.0001749531,0.001380445,0.00001974244],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003951774,0.9941944,0.0005425884,0.0001964624,0.000115391,0.000180459,0.000579094,0.00002377072,0.0002159603],"genre_scores_gemma":[0.1528584,0.8412648,0.002489515,0.0007965317,0.0002745923,0.0009845388,0.0009956518,0.00003386139,0.0003022021],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01668251,"threshold_uncertainty_score":0.06446844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07090975319869,"score_gpt":0.4118882744222543,"score_spread":0.3409785212235643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}