{"id":"W4409920110","doi":"10.1002/pro.70139","title":"Structure and inhibition of diaminopimelic acid epimerase by slow‐binding <i>α</i>‐methyl amino acids","year":2025,"lang":"en","type":"article","venue":"Protein Science","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Stereochemistry; Enzyme; Amino acid; Cysteine; Diaminopimelic acid; Active site; Biosynthesis; Biochemistry; Peptidoglycan; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006125132,0.0001540236,0.000193383,0.0002119512,0.0003370417,0.0001227838,0.0002587,0.0000845231,0.0001019563],"category_scores_gemma":[0.0002644759,0.0001298064,0.0000263928,0.0008959651,0.0008134423,0.0006420629,0.0001704907,0.0001293473,0.000007806548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005293362,"about_ca_system_score_gemma":0.0001230819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004866292,"about_ca_topic_score_gemma":0.00000609745,"domain_scores_codex":[0.9984328,0.00005400733,0.0002720898,0.0005079122,0.0004112036,0.0003219776],"domain_scores_gemma":[0.9993161,0.00003268823,0.0001446479,0.0002912976,0.0001293654,0.00008589341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001578859,0.00000957269,0.0006225323,0.0000523075,0.000001585862,7.807143e-7,0.0001329822,0.000001677701,0.9928173,0.001632416,0.0001480535,0.004565026],"study_design_scores_gemma":[0.0002401434,0.00006655107,0.001569501,0.00007821553,0.00001050176,0.000002891848,0.00005734592,0.00003884193,0.994576,0.002966623,0.0002665268,0.0001269017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994974,0.0004888818,0.002778823,0.0001588304,0.0003599645,0.0003546366,0.0000549561,0.00004731235,0.000782642],"genre_scores_gemma":[0.9956092,0.000008780068,0.003866452,0.0001163766,0.00003376013,0.00002078328,0.000006112395,0.000005848769,0.0003327515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004438124,"threshold_uncertainty_score":0.529335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00585587250666248,"score_gpt":0.2349795966760725,"score_spread":0.2291237241694101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}