{"id":"W4409922536","doi":"10.1038/s41698-025-00906-9","title":"Trans-ancestry transcriptome-wide association and functional studies to uncover novel susceptibility genes and therapeutic targets for colorectal cancer","year":2025,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Cancer Research UK; National Science and Technology Major Project; Zhejiang University; Darwin Trust of Edinburgh; Science Fund for Distinguished Young Scholars of Zhejiang Province; National Natural Science Foundation of China","keywords":"Transcriptome; Biology; Colorectal cancer; Carcinogenesis; Gene; Oncogene; Genetics; Cancer; Mechanism (biology); Cancer research; Gene expression; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005557328,0.0001232304,0.0002350404,0.00005854008,0.0001555315,0.00001827174,0.00006647564,0.0002133555,0.00001393382],"category_scores_gemma":[0.0004725733,0.0001059695,0.00005677689,0.00008867081,0.00007290861,0.000006231262,0.00005029834,0.00009076432,3.461805e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001520199,"about_ca_system_score_gemma":0.0002080689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002634524,"about_ca_topic_score_gemma":0.001148696,"domain_scores_codex":[0.9989425,0.00007982397,0.0002005,0.0004052568,0.0001243064,0.0002476456],"domain_scores_gemma":[0.9990807,0.0004611355,0.00004773651,0.00009150346,0.0002452474,0.00007366417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001185716,0.00007199701,0.04778539,0.0000400199,0.0002067213,2.837959e-7,0.0001207122,0.00009514458,0.8939444,0.00002733393,0.004260628,0.05226164],"study_design_scores_gemma":[0.006211761,0.003196286,0.3486027,0.00006687705,0.0001651276,0.000004858692,0.0008285014,0.0006023973,0.268514,0.001482629,0.369883,0.0004418173],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736574,0.009414264,0.01277071,0.003080205,0.000391731,0.000537137,0.00006496409,0.000008059288,0.00007557713],"genre_scores_gemma":[0.9931177,0.002179635,0.0009606362,0.001340099,0.0001107489,0.0002476137,0.00002245942,0.000009191066,0.002011843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6254304,"threshold_uncertainty_score":0.4321312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04399743953601849,"score_gpt":0.3723965176097422,"score_spread":0.3283990780737238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}